CAJ | 학술논문

目的探讨黄精多糖对高脂血症实验兔动脉粥样硬化斑块的消退作用.方法将40只新西兰兔分为正常对照组(饲普通饲料)、模型组(饲胆固醇饲料)、辛伐他汀组(饲胆固醇饲料+辛伐他汀)、黄精多糖组(饲胆固醇饲料+黄精多糖),分笼喂养8周.分别于实验开始时、第2周末和第8周末,采用酶法检测血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂蛋白(a)[Lp(a)]水平.第8周末处死动物,光镜观察主动脉粥样硬化斑块消退情况.结果实验前各组血脂检测指标差异无统计学意义.实验第2周末(治疗前),模型组、辛伐他汀组和黄精多糖组血清TC分别为(10.2 ±1.6)、(11.0 ±1.8)、(11.2±1.9)mmol/L,LDL-C分别为(9.85±1.65)、(9.80±1.54)、(10.08±1.88)mmol/L,Lp(a)分别为(656±106)、(700±151)、(666±111)mg/L均显著高于正常对照组[(1.3±0.3)mmol/L、(0.55±0.15)mmol/L、(106±15)mg/L,P＜0.01].实验第8周末黄精多糖干预组TC、LDL-C、Lp(a)均显著低于治疗前[(6.0±2.0)mmol/L vs(11.2±1.9)mmol/L、(4.25±1.35)mmol/L vs(10.08±1.88)mmol/L、(55±14)mg/Lvs(666±111)mg/L,P＜0.01],与模型组比较,黄精多糖组主动脉粥样硬化斑块基本消退.结论一定剂量的黄精多糖(1.6 ml·kg-1·d-1)具有消退实验性高脂血症家兔主动脉粥样硬化斑块的作用.
목적 탐토황정다당대고지혈증실험토동맥죽양경화반괴적소퇴작용.방법 장40지신서란토분위정상대조조(사보통사료)、모형조(사담고순사료)、신벌타정조(사담고순사료+신벌타정)、황정다당조(사담고순사료+황정다당),분롱위양8주.분별우실험개시시、제2주말화제8주말,채용매법검측혈청총담고순(TC)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、지단백(a)[Lp(a)]수평.제8주말처사동물,광경관찰주동맥죽양경화반괴소퇴정황.결과 실험전각조혈지검측지표차이무통계학의의.실험제2주말(치료전),모형조、신벌타정조화황정다당조혈청TC분별위(10.2 ±1.6)、(11.0 ±1.8)、(11.2±1.9)mmol/L,LDL-C분별위(9.85±1.65)、(9.80±1.54)、(10.08±1.88)mmol/L,Lp(a)분별위(656±106)、(700±151)、(666±111)mg/L균현저고우정상대조조[(1.3±0.3)mmol/L、(0.55±0.15)mmol/L、(106±15)mg/L,P＜0.01].실험제8주말황정다당간예조TC、LDL-C、Lp(a)균현저저우치료전[(6.0±2.0)mmol/L vs(11.2±1.9)mmol/L、(4.25±1.35)mmol/L vs(10.08±1.88)mmol/L、(55±14)mg/Lvs(666±111)mg/L,P＜0.01],여모형조비교,황정다당조주동맥죽양경화반괴기본소퇴.결론 일정제량적황정다당(1.6 ml·kg-1·d-1)구유소퇴실험성고지혈증가토주동맥죽양경화반괴적작용.
Objective To study the effect of polygona-polysaccharose on the elimination of atheromatous plaque.Methods Thirty adult New Zealand rabbits were fed with high-fat and cholesterol forage for 8 weeks to establish hyperlipidemia animal models and then randomly divided into 3 equal groups:model group,simvastatin group receiving simvastatin orally,and polygona-polysaccharose group receiving polygona-polysaccharose orally.Ten rabbits were fed with normal food as control forage.At weeks 0,2,and 8 the levels of total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),and lipoprotein(a)[Lp(a)]were determined with enzyme method.At the end of the week 8,all rabbits were killed to observe the elimination of aorta atheromatous plaque by microscope.Results Before the experiment,there were no significant differences in the levels of serum lipids among all groups.At the end of week 2(before treatment),the levels of serum TC of the model group,simvastatin group,and polygona-polysaccharose group were(10.2 ±1.6)mmol/L,(11 ±1.8)mmol/L,and(11.2 ±1.9)mmol/L respectively,the LDL-C levels of the 3 groups were(9.85±1.65)mmol/L,(9.80 ±1.54)mmol/L,and(10.08±1.88)mmol/L respectively,the Lp(a)levels of the 3 groups were(656 ±106)mmol/L,(700 ±151)mmol/L,and(666±111)mmol/L respectively,all significantly higher than that of the control group[(1.3 ±0.3)mmol/L,(0.55 ±0.15)mmol/L,and(106 ±15)mg/L respectively,all P＜0.01].At the end of week 8(after treatment),the levels of serum TC,LDL-C,and Lp(a)of the polygona-polysaccharose group were(6.0 ±2.0)mmol/L,(4.25 ±1.35)mmol/L,and(55 ±14)mg/Lrespectively,all significantly lower than that at the end of week 2 [(11.2±1.9)mmol/L,(10.08 ±1.88)mmol/L,and(666 ±111)mg/L respectively,all P＜0.01].The aorta atheromatous plaques in the polygona-polysaccharose group were basically eliminated compared with that in the model group.Conclusion