中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2012年
1期
50-52
,共3页
王静%牟建军%任洁%刘卫民%方媛%刘治全
王靜%牟建軍%任潔%劉衛民%方媛%劉治全
왕정%모건군%임길%류위민%방원%류치전
高血压%危险因素%动脉硬化%内皮功能
高血壓%危險因素%動脈硬化%內皮功能
고혈압%위험인소%동맥경화%내피공능
Hypertension%Risk factors%Arteriosclerosis%Endothelial function
目的 探讨青年高血压血管内皮功能损伤及其早期动脉粥样硬化改变.方法 2005年3 -4月在陕西汉中七里、老君、沙沿3个乡20个村中,按数字表法随机抽取6个村的20 ～ 35岁农村青年进行血压等相关因素调查.检出高血压患者97例(高血压组),血压正常者400名(正常组).采用高分辨率血管超声法检测患者肱动脉血流介导的内皮依赖性血管舒张功能(FMD),颈动脉内膜中膜厚度(IMT)以及其他生化指标.结果 青年高血压组BMI[(24.7 ±4.3)kg/m2]、腰围[(84.1±11.7) cm]、臀围[(92.5±7.4)cm]、TC[(4.6±0.8) mmol/L]、LDL-C[(2.8±0.5) mmol/L]、TG[( 1.7±1.1) mmol/L]及血胰岛素(INS)[(8.6±4.4)mIu/L]均高于血压正常组[分别为(22.1 ±3.0) kg/m2、(76.7±8.9) cm、(88.9±5.6) cm、(4.3±0.7) mmol/L、(2.6±0.4) mmol/L、( 1.4±0.8)mmol/L、(6.9 ±2.1)mlu/L],差异均有统计学意义(P值均＜0.05).高血压组血流介导的FMD低于血压正常组,分别为(0.103 ±0.04)％和(0.117±0.05)％(P＜0.05)；两组IMT分别为(0.49 ±0.07)mm和(0.48±0.07) mm,差异无统计学意义(P＞0.05).结论 青年高血压较早存在内皮依赖性血管FMD损害,并先于颈动脉内膜-IMT的改变.
目的 探討青年高血壓血管內皮功能損傷及其早期動脈粥樣硬化改變.方法 2005年3 -4月在陝西漢中七裏、老君、沙沿3箇鄉20箇村中,按數字錶法隨機抽取6箇村的20 ～ 35歲農村青年進行血壓等相關因素調查.檢齣高血壓患者97例(高血壓組),血壓正常者400名(正常組).採用高分辨率血管超聲法檢測患者肱動脈血流介導的內皮依賴性血管舒張功能(FMD),頸動脈內膜中膜厚度(IMT)以及其他生化指標.結果 青年高血壓組BMI[(24.7 ±4.3)kg/m2]、腰圍[(84.1±11.7) cm]、臀圍[(92.5±7.4)cm]、TC[(4.6±0.8) mmol/L]、LDL-C[(2.8±0.5) mmol/L]、TG[( 1.7±1.1) mmol/L]及血胰島素(INS)[(8.6±4.4)mIu/L]均高于血壓正常組[分彆為(22.1 ±3.0) kg/m2、(76.7±8.9) cm、(88.9±5.6) cm、(4.3±0.7) mmol/L、(2.6±0.4) mmol/L、( 1.4±0.8)mmol/L、(6.9 ±2.1)mlu/L],差異均有統計學意義(P值均＜0.05).高血壓組血流介導的FMD低于血壓正常組,分彆為(0.103 ±0.04)％和(0.117±0.05)％(P＜0.05)；兩組IMT分彆為(0.49 ±0.07)mm和(0.48±0.07) mm,差異無統計學意義(P＞0.05).結論 青年高血壓較早存在內皮依賴性血管FMD損害,併先于頸動脈內膜-IMT的改變.
목적 탐토청년고혈압혈관내피공능손상급기조기동맥죽양경화개변.방법 2005년3 -4월재협서한중칠리、로군、사연3개향20개촌중,안수자표법수궤추취6개촌적20 ～ 35세농촌청년진행혈압등상관인소조사.검출고혈압환자97례(고혈압조),혈압정상자400명(정상조).채용고분변솔혈관초성법검측환자굉동맥혈류개도적내피의뢰성혈관서장공능(FMD),경동맥내막중막후도(IMT)이급기타생화지표.결과 청년고혈압조BMI[(24.7 ±4.3)kg/m2]、요위[(84.1±11.7) cm]、둔위[(92.5±7.4)cm]、TC[(4.6±0.8) mmol/L]、LDL-C[(2.8±0.5) mmol/L]、TG[( 1.7±1.1) mmol/L]급혈이도소(INS)[(8.6±4.4)mIu/L]균고우혈압정상조[분별위(22.1 ±3.0) kg/m2、(76.7±8.9) cm、(88.9±5.6) cm、(4.3±0.7) mmol/L、(2.6±0.4) mmol/L、( 1.4±0.8)mmol/L、(6.9 ±2.1)mlu/L],차이균유통계학의의(P치균＜0.05).고혈압조혈류개도적FMD저우혈압정상조,분별위(0.103 ±0.04)％화(0.117±0.05)％(P＜0.05)；량조IMT분별위(0.49 ±0.07)mm화(0.48±0.07) mm,차이무통계학의의(P＞0.05).결론 청년고혈압교조존재내피의뢰성혈관FMD손해,병선우경동맥내막-IMT적개변.
Objective To explore young hypertensive people's vascular endothelial dysfunction and the early atherosclerosis changes.Methods Rural youth subjects aged 20 to 35 in 6 villages were randomly selected from 20 villages of 3 townships,including Qili,Laojun and Shayan,in Hanzhong,Shanxi,China,from March to April of 2005,to survey their blood pressure and other related factors.97 subjects with high blood pressure (hypertensive group) were detected while 400 with normal blood pressure ( normal group).We measured their brachial artery flow-mediated vascular endothelial-dependent diastolic function (FMD) and the carotid intima-media thickness (IMT) by high resolution vascular ultrasound method,and other biochemical indexes.Results The body mass index (BMI) ((24.7 ±4.3)kg/m2),waistline ((84.1 ±11.7 ) cm),hipline ( ( 92.5 ± 7.4 ) cm ),TC ( ( 4.6 ± 0.8 ) mmol/L),LDL-C ( ( 2.8 ± 0.5 ) mmol/L),TG ( ( 1.7 ± 1.1 )mmol/L) and the blood insulin (INS) ( (8.6 ±4.4) mIu/L) were all significantly increased in young hypertensive group than those in normotensive group (respectively were (22.1 ± 3.0 ) kg/m2,(76.7 ± 8.9 ) cm,( 88.9 ± 5.6 ) cm,(4.3 ± 0.7 ) mmol/L,( 2.6 ± 0.4 ) mmoL/L,( 1.4 ± 0.8 ) mmol/L and (6.9±2.1 )mIu/L)(P ＜0.05).The FMD of the brachial artery in hypertensive group was markedly lower than normal group ( ( 0.103 ± 0.04 ) ％ and ( 0.117 ± 0.05 ) ％,P ＜ 0.05 ).The IMT of two groups were ( 0.49 ± 0.07 )mm and ( 0.48 ± 0.07 ) rmm,but there was no statistically significant differences ( P ＞ 0.05 ).Conclusion Young hypertensive people with a few cardiovascular risk factors earlier appear dysfunction of the flow-mediated vascular endothelial-dependent dilation,which is prior to the increase in carotid IMT.
