CAJ | 학술논문

研究了白藜芦醇苷(polydatim,PD)的抗血栓形成作用及其作用机制.采用小鼠尾静脉注射花生四烯酸(arachidonic acid,AA)、电刺激大鼠颈动脉血栓形成方法评价PD的抗血栓形成作用;运用放射免疫法测定polydatin对兔血浆血栓素B2(thromboxane B2,TXB2)及6-酮-前列腺素F1α(6-keto-prostaglandin F1α,6-keto-PGF1α)水平的影响.结果显示PD对AA、电刺激大鼠颈动脉引起的血栓形成具有明显的对抗作用;PD亦能降低兔血浆TXB2含量并升高6-Keto-PGF1α水平.本实验提示PD有明显的抗血栓形成作用,其机制可能与其降低血浆TXB2含量及升高6-Keto-PGF1α水平密切相关.
연구료백려호순감(polydatim,PD)적항혈전형성작용급기작용궤제.채용소서미정맥주사화생사희산(arachidonic acid,AA)、전자격대서경동맥혈전형성방법평개PD적항혈전형성작용;운용방사면역법측정polydatin대토혈장혈전소B2(thromboxane B2,TXB2)급6-동-전렬선소F1α(6-keto-prostaglandin F1α,6-keto-PGF1α)수평적영향.결과현시PD대AA、전자격대서경동맥인기적혈전형성구유명현적대항작용;PD역능강저토혈장TXB2함량병승고6-Keto-PGF1α수평.본실험제시PD유명현적항혈전형성작용,기궤제가능여기강저혈장TXB2함량급승고6-Keto-PGF1α수평밀절상관.
Antithrombotic effects of polydatin(PD) and its influence on plasma thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α(6-keto-PGF1α) leves were investigated. The methods of injection of arachidonic acid (AA) into mouse vein and electrically stimulated carotid thrombosis in rats were used to evaluate the antithrombotic effects of PD; TXB2 and 6-keto-PGF1α levels were monitored by the radioimmunoassay. The results showed that PD obviously protected against thrombosis caused by AA and electrical stimulation. PD also significantly decreased plasma TXB2 level and increased plasma 6-keto-PGF1α level simultaneously. It is suggested that polydatin should have evident antithrombotic effects and the mechanisms may be intimately related to its decrease of plasma TXB2 and increase of 6-keto-PGF1α.