国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2008年
6期
484-486
,共3页
埃希氏菌属%克雷伯菌,肺炎%β-内酰胺酶类%抗药性,细菌
埃希氏菌屬%剋雷伯菌,肺炎%β-內酰胺酶類%抗藥性,細菌
애희씨균속%극뢰백균,폐염%β-내선알매류%항약성,세균
Escherichia%Klebsiella pneumoniae%beta Lactamases%Drug Resistance,Bacterial
目的 了解医院1998年1月至2006年12月期间临床分离的大肠埃希菌和肺炎克雷伯菌产超广谱β-内酰胺酶(ESBLs)的情况,监测并分析大肠埃希菌和肺炎克雷伯菌的耐药特性,为临床合理使用抗生素提供指导.方法 对分离的大肠埃希菌和肺炎克雷伯菌采用纸片扩散法进行药物敏感试验,用筛选试验和确证试验确认产ESBLs菌株,用WHONET 5.4软件进行数据分析.结果 947株大肠埃希菌中,产ESBLs的有311株,占32.8%;293株肺炎克雷伯菌中,产ESBLs的有69株,占23.5%.产ESBLs菌株的耐药性显著高于非产ESBLs菌株(P<0.05),产ESBLs菌株呈现多重耐药.结论 医院产ESBLs菌的阳性率较高,应加强对产ESBLs菌株的耐药性监测,合理使用抗菌药物,防止ESBLs菌株的增长、扩散与流行.
目的 瞭解醫院1998年1月至2006年12月期間臨床分離的大腸埃希菌和肺炎剋雷伯菌產超廣譜β-內酰胺酶(ESBLs)的情況,鑑測併分析大腸埃希菌和肺炎剋雷伯菌的耐藥特性,為臨床閤理使用抗生素提供指導.方法 對分離的大腸埃希菌和肺炎剋雷伯菌採用紙片擴散法進行藥物敏感試驗,用篩選試驗和確證試驗確認產ESBLs菌株,用WHONET 5.4軟件進行數據分析.結果 947株大腸埃希菌中,產ESBLs的有311株,佔32.8%;293株肺炎剋雷伯菌中,產ESBLs的有69株,佔23.5%.產ESBLs菌株的耐藥性顯著高于非產ESBLs菌株(P<0.05),產ESBLs菌株呈現多重耐藥.結論 醫院產ESBLs菌的暘性率較高,應加彊對產ESBLs菌株的耐藥性鑑測,閤理使用抗菌藥物,防止ESBLs菌株的增長、擴散與流行.
목적 료해의원1998년1월지2006년12월기간림상분리적대장애희균화폐염극뢰백균산초엄보β-내선알매(ESBLs)적정황,감측병분석대장애희균화폐염극뢰백균적내약특성,위림상합리사용항생소제공지도.방법 대분리적대장애희균화폐염극뢰백균채용지편확산법진행약물민감시험,용사선시험화학증시험학인산ESBLs균주,용WHONET 5.4연건진행수거분석.결과 947주대장애희균중,산ESBLs적유311주,점32.8%;293주폐염극뢰백균중,산ESBLs적유69주,점23.5%.산ESBLs균주적내약성현저고우비산ESBLs균주(P<0.05),산ESBLs균주정현다중내약.결론 의원산ESBLs균적양성솔교고,응가강대산ESBLs균주적내약성감측,합리사용항균약물,방지ESBLs균주적증장、확산여류행.
Objective To investigate the status of extended-spectrum β-lactamases (ESBLs) production by Escherichia coli and Klebsiella pheumoniae, analyze the characteristics of drug resistance of Escherichia coli and Klebsiella pheumoniae in our hospital from Jan 1998 to Dec 2006, in order to provide a guidance to clinical rational use of antibiotics.Methods Disc diffusion test (K-B method) was used to study the drug resistance of E. coli and K.pheumoniae isolates, and ESBLs-producing strains were identified with screening test and confirmatory test. WHONET5.4 software was apllied to performing data analysis.Results In 947 strains of E. coli, 311 strains (32.8%) were detected to produce ESBLs;in 293 strains of K.pheumoniae, 69 ESBLs-producing strains (23.5%) were detected. The resistance rate of ESBLs-producing strains was significantly higher than that of ESBLs non-producing ones (P<0.05), and but ESBLs-producing strains displayed multi-resistant.Conclusion The positive rate of ESBLs producing strains is higher in our hospital. Drug resistance monitoring should be strenghed to rationally use antibacterials and to prevent increase, prevalence and outbreak of ESBLs producing strains.
