国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
5期
384-387
,共4页
过氧化物酶体增殖剂活化受体γ激动剂%哮喘%呼吸道合胞病毒
過氧化物酶體增殖劑活化受體γ激動劑%哮喘%呼吸道閤胞病毒
과양화물매체증식제활화수체γ격동제%효천%호흡도합포병독
Peroxisome proliferator-activated receptor γ agonists%Asthma%Respiratory syncytial virus
过氧化物酶体增殖剂活化受体γ(PPARγ)是一个由配体激活的核转录因子,属于核激素受体(nuclear hormone receptor)超家族成员.被激活后,该受体除参与脂质和脂蛋白代谢,还涉及上皮细胞分化,单核/巨噬细胞等炎症细胞的活化,血管舒缩以及动脉粥样硬化形成,甚至肿瘤增殖等.本文对现有的PPARγ激动剂在支气管哮喘和呼吸道合胞病毒感染中的作用作一综述.
過氧化物酶體增殖劑活化受體γ(PPARγ)是一箇由配體激活的覈轉錄因子,屬于覈激素受體(nuclear hormone receptor)超傢族成員.被激活後,該受體除參與脂質和脂蛋白代謝,還涉及上皮細胞分化,單覈/巨噬細胞等炎癥細胞的活化,血管舒縮以及動脈粥樣硬化形成,甚至腫瘤增殖等.本文對現有的PPARγ激動劑在支氣管哮喘和呼吸道閤胞病毒感染中的作用作一綜述.
과양화물매체증식제활화수체γ(PPARγ)시일개유배체격활적핵전록인자,속우핵격소수체(nuclear hormone receptor)초가족성원.피격활후,해수체제삼여지질화지단백대사,환섭급상피세포분화,단핵/거서세포등염증세포적활화,혈관서축이급동맥죽양경화형성,심지종류증식등.본문대현유적PPARγ격동제재지기관효천화호흡도합포병독감염중적작용작일종술.
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear transcription factor,belonged to the nuclear hormone receptor superfamily.The receptor involved in lipid and lipoprotein metabolism, epithelial cells, monocytes/macrophages and other inflammatory cell activation,vasomotor and atherosclerosis formation,proliferation,and even cancer,while it is activated.In this paper,the effect of PPARγ agonists in bronchial asthma and respiratory syncytial virus infection is reviewed.
