中华放射学杂志
中華放射學雜誌
중화방사학잡지
Chinese Journal of Radiology
2010年
1期
57-60
,共4页
尹建忠%王建利%杨庆宪%祁吉
尹建忠%王建利%楊慶憲%祁吉
윤건충%왕건리%양경헌%기길
内嗅皮觉%磁共振成像%阿尔茨海默病%认知障碍
內嗅皮覺%磁共振成像%阿爾茨海默病%認知障礙
내후피각%자공진성상%아이자해묵병%인지장애
Entorhinal cortex%Magnetic resonance imaging%Alzheimer disease%Cognition disorders
目的 确定阿尔茨海默病(AD)与轻度认知障碍(MCI)患者中初级嗅觉皮层的萎缩程度,并且探讨解剖学萎缩与嗅觉功能减低的内在联系.方法 选取12例AD、8例MCI患者和20名正常志愿者(NC),进行标准的嗅觉功能和神经学评分,而后进行高分辨率MRI和嗅觉fMRI.于T_1WI上确定初级嗅觉皮层的边界,并测量常规初级嗅觉皮层的容积,将此容积保存为ROI.然后采用事件相关的实验设计进行嗅觉fMRI,测量初级嗅觉皮层ROI内的激活体素.3组间的初级嗅觉皮层体积和激活范围比较采用Kruskal-Wallis秩和检验,如存在统计学差异则进行Bonferroni法两两比较.解剖学体积与激活范围情况的相关性在控制年龄因素下进行偏相关性分析.结果 NC、MCI和AD组初级嗅觉皮层的体积范围分别为3024～4734、1409～4553和1561～3759 mm~3,中位数分别为3749、2752和2156 mm~3;激活体素范围分别为0～2360、0～2160和0～100 mm~3,中位数分别为430、40和0 mm~3,NC、MCI和AD组初级嗅觉皮层体积和激活体素依次降低,差异有统计学意义(H值分别为14.942、16.587,P值均<0.05).初级嗅觉皮层内的激活与皮层体积的萎缩存在弱相关性(r=0.364,P=0.023).结论 AD初级嗅觉皮层存在明显萎缩与功能障碍,可以为AD的嗅觉功能障碍研究提供神经病理学和神经功能学依据.
目的 確定阿爾茨海默病(AD)與輕度認知障礙(MCI)患者中初級嗅覺皮層的萎縮程度,併且探討解剖學萎縮與嗅覺功能減低的內在聯繫.方法 選取12例AD、8例MCI患者和20名正常誌願者(NC),進行標準的嗅覺功能和神經學評分,而後進行高分辨率MRI和嗅覺fMRI.于T_1WI上確定初級嗅覺皮層的邊界,併測量常規初級嗅覺皮層的容積,將此容積保存為ROI.然後採用事件相關的實驗設計進行嗅覺fMRI,測量初級嗅覺皮層ROI內的激活體素.3組間的初級嗅覺皮層體積和激活範圍比較採用Kruskal-Wallis秩和檢驗,如存在統計學差異則進行Bonferroni法兩兩比較.解剖學體積與激活範圍情況的相關性在控製年齡因素下進行偏相關性分析.結果 NC、MCI和AD組初級嗅覺皮層的體積範圍分彆為3024～4734、1409～4553和1561～3759 mm~3,中位數分彆為3749、2752和2156 mm~3;激活體素範圍分彆為0～2360、0～2160和0～100 mm~3,中位數分彆為430、40和0 mm~3,NC、MCI和AD組初級嗅覺皮層體積和激活體素依次降低,差異有統計學意義(H值分彆為14.942、16.587,P值均<0.05).初級嗅覺皮層內的激活與皮層體積的萎縮存在弱相關性(r=0.364,P=0.023).結論 AD初級嗅覺皮層存在明顯萎縮與功能障礙,可以為AD的嗅覺功能障礙研究提供神經病理學和神經功能學依據.
목적 학정아이자해묵병(AD)여경도인지장애(MCI)환자중초급후각피층적위축정도,병차탐토해부학위축여후각공능감저적내재련계.방법 선취12례AD、8례MCI환자화20명정상지원자(NC),진행표준적후각공능화신경학평분,이후진행고분변솔MRI화후각fMRI.우T_1WI상학정초급후각피층적변계,병측량상규초급후각피층적용적,장차용적보존위ROI.연후채용사건상관적실험설계진행후각fMRI,측량초급후각피층ROI내적격활체소.3조간적초급후각피층체적화격활범위비교채용Kruskal-Wallis질화검험,여존재통계학차이칙진행Bonferroni법량량비교.해부학체적여격활범위정황적상관성재공제년령인소하진행편상관성분석.결과 NC、MCI화AD조초급후각피층적체적범위분별위3024～4734、1409～4553화1561～3759 mm~3,중위수분별위3749、2752화2156 mm~3;격활체소범위분별위0～2360、0～2160화0～100 mm~3,중위수분별위430、40화0 mm~3,NC、MCI화AD조초급후각피층체적화격활체소의차강저,차이유통계학의의(H치분별위14.942、16.587,P치균<0.05).초급후각피층내적격활여피층체적적위축존재약상관성(r=0.364,P=0.023).결론 AD초급후각피층존재명현위축여공능장애,가이위AD적후각공능장애연구제공신경병이학화신경공능학의거.
Objective To determine the volume reduction of the primary olfactory cortex (POC) in patients with Alzheimer disease (AD) and investigate the potential relationship of functional olfactory activation and anatomical atrophy changes. Methods Twelve patients with AD, eight patients with mild cognitive impairment (MCI) and twenty normal controls (NC) underwent standardized UPSIT (University of Pennsylvania smell identification test) behavior smell test and neuropsychological tests. Then all of the subjects underwent the high resolution MRI and an olfactory fMRI scan on a 3T system. Volumetric measurement of the POC was conducted and the areas were also saved as a ROI which would be used during the processing of fMRI data to get the activation voxels in local region. The Kruskal-Wallis rank test was used to examine the significance of POC volume and activation in three groups, If P-value was less than 0.05,Bonferroni method was used for multiple comparisons. The correlation between the anatomical volume and functional activation was analyzed with partial correlation adjusted for age. Results The POC volume of NC, MCI and AD groups were 3024--4734, 1409--4553 and 1561--3759 mm~3, and the medians were 3749, 2752 and 2156 mm~3. The activation voxels of each group were 0--2360, 0--2160 and 0--100 mm~3, while the medians were 430, 40 and 0 mm~3. There were significant differences of both POC volume atrophy and activation between the three groups, with a trend of reduction from NC to MCI to AD group (H is 14.942 and 16.587, both P<0.05). The volume of olfactory activation at POC was highly correlated with the volume of POC (r=0.364, P=0.023). Conclusions In this study, we explored the morphological and functional changes in the POC. It is revealed that POC suffers prominent local atrophy and dysfunction as well as hippocampus in AD. These results can provide neuropathological and neurofunctional bases for olfactory deficit in Alzheimer Disease.
