CAJ | 학술논문

目的研究颞叶内侧亚结构体积变化对阿尔茨海默病( Alzheimer's disease,AD)的诊断价值.方法依据DSM-Ⅳ标准,入组23例AD,其中男9例,女14例；入组23例正常对照老人,其中男11例,女12例.应用3D-MRI测量海马、杏仁核、内嗅皮质、旁嗅皮质等指标.在GE后处理工作站上对3D-MRI资料进行后处理及标准化,使用SPSS11.0软件进行统计分析.结果旁嗅皮质总体积与认知评估量表得分有显著相关性.各结构体积诊断AD的灵敏度和特异度分别为:海马总体积(73.9％,97％)；杏仁核总体积(39.1％,95.7％)；内嗅皮质总体积(73.9％,95.7％)；旁嗅皮质总体积(95.7％,87.0％)；颞角总体积(34.8％,39.1％).总体判别函数为颞角总体积×3.887+旁嗅皮质总体积×5.960 -内嗅皮质总体积×0.074+杏仁体总体积×3.489+海马总体积×6.656 -22.449,总体判别正确率为91.3％,旁嗅皮质总体积的标准化系数及与函数的相关系数均最大.结论旁嗅皮质总体积在早中期阿尔茨海默病的诊断中起重要作用,可利用内侧颞叶亚结构体积变化对早中期AD进行诊断.
목적 연구섭협내측아결구체적변화대아이자해묵병( Alzheimer's disease,AD)적진단개치.방법 의거DSM-Ⅳ표준,입조23례AD,기중남9례,녀14례；입조23례정상대조노인,기중남11례,녀12례.응용3D-MRI측량해마、행인핵、내후피질、방후피질등지표.재GE후처리공작참상대3D-MRI자료진행후처리급표준화,사용SPSS11.0연건진행통계분석.결과 방후피질총체적여인지평고량표득분유현저상관성.각결구체적진단AD적령민도화특이도분별위:해마총체적(73.9％,97％)；행인핵총체적(39.1％,95.7％)；내후피질총체적(73.9％,95.7％)；방후피질총체적(95.7％,87.0％)；섭각총체적(34.8％,39.1％).총체판별함수위섭각총체적×3.887+방후피질총체적×5.960 -내후피질총체적×0.074+행인체총체적×3.489+해마총체적×6.656 -22.449,총체판별정학솔위91.3％,방후피질총체적적표준화계수급여함수적상관계수균최대.결론 방후피질총체적재조중기아이자해묵병적진단중기중요작용,가이용내측섭협아결구체적변화대조중기AD진행진단.
Objective To study the metastructure volumes of medial temporal lobe in diagnosis the patients with Alzheimer's disease (AD) using 3 dimensional MRI.Methods 23 AD patients according to DSM-Ⅳ criteria and 23 normal controls (NC) were examined with 3D-MRI.Hippocampus formation,amygdala,entorhinal cortex ( EC ),perirhinal cortex ( PC),and comu temporale were measured with 3D-MRI.Results Sensitivity and specificity of diagnosis AD were 73.9％,97％ ( Hippocampus formation) ;39.1％,95.7％ (amygdala) ;73.9％,95.7％ (EC) ;95.7％,87.0％ (PC) and 34.8％,39.1％ ( cornu temporale).Overall discriminate function =cornu temporal × 3.887 + PC × 5.960 - EC × 0.074 + amygdale × 3.489 + hippocampus formation × 6.656- 22.449.Over-all-accuracy was 91.3％.Conclusion The total volume of PC can better diagnosis the mild to moderate AD than other structure of medial temporal lobe.The changes of the medial temporal lobe volume could be used in diagnosis the patients with Alzheimer's disease.