波谱学杂志
波譜學雜誌
파보학잡지
CHINESE JOURNAL OF MAGNETIC RESONANCE
2010年
4期
617-622
,共6页
李英俊%李春燕%靳焜%安静%王雷雷%赵星
李英俊%李春燕%靳焜%安靜%王雷雷%趙星
리영준%리춘연%근혼%안정%왕뢰뢰%조성
核磁共振(NMR)%归属%2D%NMR%2-苯并噁唑啉酮%咪唑[2,1-b][1,3,4]噻二唑
覈磁共振(NMR)%歸屬%2D%NMR%2-苯併噁唑啉酮%咪唑[2,1-b][1,3,4]噻二唑
핵자공진(NMR)%귀속%2D%NMR%2-분병오서람동%미서[2,1-b][1,3,4]새이서
NMR%assignment%2D NMR%2-benzoxazolinone%imidazo[2,1-b][1,3,4]thiadiazole
许多文献已报道, 含有咪唑[2,1-b][1,3,4]噻唑环的衍生物具有抗癌、抗结核、抗菌、抗真菌、抗惊厥、止痛等活性.该文合成了一个新的在医药方面具有潜在应用价值的咪唑[2,1-b][1,3,4]噻二唑衍生物, 即2-(2-苯并噁唑啉酮-3-甲基)-6-苯基-咪唑[2,1-b][1,3,4]噻二唑, 并利用2D NMR技术对其 1 H NMR 和 13C NMR谱进行了全归属.
許多文獻已報道, 含有咪唑[2,1-b][1,3,4]噻唑環的衍生物具有抗癌、抗結覈、抗菌、抗真菌、抗驚厥、止痛等活性.該文閤成瞭一箇新的在醫藥方麵具有潛在應用價值的咪唑[2,1-b][1,3,4]噻二唑衍生物, 即2-(2-苯併噁唑啉酮-3-甲基)-6-苯基-咪唑[2,1-b][1,3,4]噻二唑, 併利用2D NMR技術對其 1 H NMR 和 13C NMR譜進行瞭全歸屬.
허다문헌이보도, 함유미서[2,1-b][1,3,4]새서배적연생물구유항암、항결핵、항균、항진균、항량궐、지통등활성.해문합성료일개신적재의약방면구유잠재응용개치적미서[2,1-b][1,3,4]새이서연생물, 즉2-(2-분병오서람동-3-갑기)-6-분기-미서[2,1-b][1,3,4]새이서, 병이용2D NMR기술대기 1 H NMR 화 13C NMR보진행료전귀속.
Many compounds containing imidazo[2,1-b][1,3,4]thiadiazole ring showed pharmacological properties such as anticancer, antitubercular, antibacterial, antifungal, anticonvulsant, analgesic activities.In this paper, a novel compound which may have potential pharmaceutical applications, 2-[(2-benzoxazolinone-3-yl)methyl]-6-phenyl-imidazo[2,1-b][1,3,4] thiadiazole, was synthesized.Its 1 H and 13C NMR chemical shifts were assigned using 2D NMR techniques, including gHMQC, gHMBC and 1 H-1 H COSY.
