CAJ | 학술논문

脑缺血的实验研究对于理解缺血性脑损伤的发病机制具有重要的作用,但与临床治疗策略的相关性存在一定的局限性,主要原因之一就是实验动物模型和实验方法不能或只能部分重复自然脑缺血的病理生理学过程.文章对常用的实验动物模型及其体外和体内评价方法做了综述.
뇌결혈적실험연구대우리해결혈성뇌손상적발병궤제구유중요적작용,단여림상치료책략적상관성존재일정적국한성,주요원인지일취시실험동물모형화실험방법 불능혹지능부분중복자연뇌결혈적병리생이학과정.문장대상용적실험동물모형급기체외화체내평개방법 주료종술.
The experimental study of cerebral ischemia plays an important role for understanding the pathogenesis of ischemic brain injury, but its correlation with the clinical therapeutic strategies has certain limitations. One of its main reasons is that the experimental models and methods can not or only partially repeat the pathophysiological processes of natural cerebral ischemia. In order to promote the understanding and interpretation of the experimental data, we review the commonly used experimental animal models and modeling methods and mainly elaborate the methods of current different in vivo and in vitro clinical evaluation. Based on these studies, we believe that the standardized clinical evaluations are hugely important for assessing the experimental results and clinical transformation.