CAJ | 학술논문

目的探讨卵磷脂胆固醇酰基转移酶(1ecithin cholesterol acyltransferase,LCAT)基因608C/T和511C/T多态性与中国湖南地区汉族人群卒中发病的关系.方法选择150例脑梗死、150例脑出血患者以及122名年龄和性别相匹配的对照者,应用聚合酶链反应、单链构象多态性技术和限制性片段长度多态性技术检测LCAT基因608C/T和511C/T多态性.结果脑梗死组LCAT基因608C/T CT基因型频率(14.0%)和T等位基因频率(7.0%)均显著高于对照组(P均＜0.01),而脑出血组CT基因型频率(7.3%)和T等位基因频率(3.7%)与对照组无显著差异(P＞0.05);脑梗死组LCAT基因511C/T CT基因型频率(10.0%)和T等位基因频率(5.0%)均显著高于对照组(P均＜0.01),而脑出血组CT基因型频率(3.3%)和T等位基因频率(1.7%)与对照组无显著差异(P＞0.05).结论 LCAT基因608C/T和511C/T多态性可能与中国湖南地区汉族人群动脉粥样硬化性脑梗死发病有关,可能为该人群动脉粥样硬化性脑梗死的易感因素,而与脑出血发病无关.
목적 탐토란린지담고순선기전이매(1ecithin cholesterol acyltransferase,LCAT)기인608C/T화511C/T다태성여중국호남지구한족인군졸중발병적관계.방법 선택150례뇌경사、150례뇌출혈환자이급122명년령화성별상필배적대조자,응용취합매련반응、단련구상다태성기술화한제성편단장도다태성기술검측LCAT기인608C/T화511C/T다태성.결과 뇌경사조LCAT기인608C/T CT기인형빈솔(14.0%)화T등위기인빈솔(7.0%)균현저고우대조조(P균＜0.01),이뇌출혈조CT기인형빈솔(7.3%)화T등위기인빈솔(3.7%)여대조조무현저차이(P＞0.05);뇌경사조LCAT기인511C/T CT기인형빈솔(10.0%)화T등위기인빈솔(5.0%)균현저고우대조조(P균＜0.01),이뇌출혈조CT기인형빈솔(3.3%)화T등위기인빈솔(1.7%)여대조조무현저차이(P＞0.05).결론 LCAT기인608C/T화511C/T다태성가능여중국호남지구한족인군동맥죽양경화성뇌경사발병유관,가능위해인군동맥죽양경화성뇌경사적역감인소,이여뇌출혈발병무관.
Objective To explore the relationship between lecithin cholesterol acy ltransferase (LCAT) gene 608C/T and 511C/T polymorphisms and stroke in Chinese Han population in Hunan province. Methods One hundred fifty patients with cerebral infarction, 150patients with cerebral hemorrhage, and 122 age- and sex-matched healthy controls were selected.LCAT gene 608C/T and 511C/T polymorphisms were detected by using polyrnerase chain reaction, single strand conformation polymorphism, and restriction fragment length polymorphisms. Results The CT genotype frequency (14. 0% ) and T allele frequency (7. 0% )of the LCAT gene 608C/T in the cerebral infarction group were significantly higher than those in the control group (all P ＜0. 05), while there were no significant differences in the CT genotype frequency (7. 3% ) and T allele frequency (3.7%) between the cerebral hemorrhage group and the control group (P ＞ 0. 05). The CT genotype frequency (10. 0% ) and T allele frequency (5. 0% ) of the LCAT gene 511C/T in the cerebral infarction group were significantly higher than those in the control group (all P ＜0. 01), while there were no significant differences in the CT genotype frequency (3.3%) and T allele frequency (1.7%) between the cerebral hemorrhage group and the control group (P ＞0. 05). Conclusions The 608C/T and 511C/T polymorphisms may be associated with the occurrence of atherosclerotic cerebral infarction in Chinese Han population in Hunan province. They may be the predisposing factors for atherosclerotic cerebral infarction in this population; however, they are not associated with cerebral hemorrhage.