CAJ | 학술논문

树突细胞是一类专职的抗原提呈细胞,它们有不同的亚群.在免疫反应中,树突细胞能从微生物及细胞周边环境中接受信号从而启动和调节免疫反应.树突细胞表面表达不同的微生物受体,细胞因子受体和表面分子.其功能状态决定了是激发免疫反应还是诱导免疫耐受.因此,异常功能状态的树突细胞可引发不同的皮肤疾病,如自身免疫性疾病和癌症.反之,树突细胞也可被开发研制成疫苗用于治疗这些疾病.
수돌세포시일류전직적항원제정세포,타문유불동적아군.재면역반응중,수돌세포능종미생물급세포주변배경중접수신호종이계동화조절면역반응.수돌세포표면표체불동적미생물수체,세포인자수체화표면분자.기공능상태결정료시격발면역반응환시유도면역내수.인차,이상공능상태적수돌세포가인발불동적피부질병,여자신면역성질병화암증.반지,수돌세포야가피개발연제성역묘용우치료저사질병.
Dendritic cells (DCs), a subset of professional antigen-presenting cells, are classified into different subtypes. DCs can initiate and regulate immune responses after receiving signals from microbes and extracellular environment. They express different microbial receptors, cytokine receptors and surface molecules. The functional status of DCs determines whether they trigger immune response or induce immunotolerance. Hence, DCs with abnormal function can result in different skin diseases, including autoimmune diseases and cancers. Conversely, DCs can also be exploited for the development of vaccines to treat these diseases.