中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2008年
10期
1674-1675
,共2页
心力衰竭,充血性%C反应蛋白质
心力衰竭,充血性%C反應蛋白質
심력쇠갈,충혈성%C반응단백질
Heart failure,congestive%C-reactive protein
目的 观察充血性心力衰竭(CHF)患者血清c反应蛋白(CRP)水平与预后关系.方法 选择342例CHF患者和126例健康者,应用酶联免疫法检测血清CRP水平.结果 CHF患者血清CRP为(8.66±4.38)mg/L,健康对照者为(1.12±0.87)mv:L(P<0.01).168例左室射血分数(LVEF)≤35%者,CRP水平为(11.92±4.55)mg/L,174例LVEF>35%者,CRP为(5/88±1.92)mg/L,LVEF值与CRP水平呈负相关(r=-0.502,P<0.01).心功能为Ⅰ、Ⅱ、Ⅲ、Ⅳ级者,其血清CRP分别为(3.92±0.79)mg/L、(5.03±1.55)me/L、(8.94±2.97)mg/L、(12.21±4.43)mg/L,随访6个月.其中血清CRP≥10 mg/L者病死率32.50%(26/83);5 mg/L≤CRP<10 mg/L者,病死率10.48%(11/109);CRP<5 mg/L者病死率2.76%(4/150).结论 CHF患者血清CRP水平升高程度与心力衰竭严重程度相平行,并预示患者预后不良.
目的 觀察充血性心力衰竭(CHF)患者血清c反應蛋白(CRP)水平與預後關繫.方法 選擇342例CHF患者和126例健康者,應用酶聯免疫法檢測血清CRP水平.結果 CHF患者血清CRP為(8.66±4.38)mg/L,健康對照者為(1.12±0.87)mv:L(P<0.01).168例左室射血分數(LVEF)≤35%者,CRP水平為(11.92±4.55)mg/L,174例LVEF>35%者,CRP為(5/88±1.92)mg/L,LVEF值與CRP水平呈負相關(r=-0.502,P<0.01).心功能為Ⅰ、Ⅱ、Ⅲ、Ⅳ級者,其血清CRP分彆為(3.92±0.79)mg/L、(5.03±1.55)me/L、(8.94±2.97)mg/L、(12.21±4.43)mg/L,隨訪6箇月.其中血清CRP≥10 mg/L者病死率32.50%(26/83);5 mg/L≤CRP<10 mg/L者,病死率10.48%(11/109);CRP<5 mg/L者病死率2.76%(4/150).結論 CHF患者血清CRP水平升高程度與心力衰竭嚴重程度相平行,併預示患者預後不良.
목적 관찰충혈성심력쇠갈(CHF)환자혈청c반응단백(CRP)수평여예후관계.방법 선택342례CHF환자화126례건강자,응용매련면역법검측혈청CRP수평.결과 CHF환자혈청CRP위(8.66±4.38)mg/L,건강대조자위(1.12±0.87)mv:L(P<0.01).168례좌실사혈분수(LVEF)≤35%자,CRP수평위(11.92±4.55)mg/L,174례LVEF>35%자,CRP위(5/88±1.92)mg/L,LVEF치여CRP수평정부상관(r=-0.502,P<0.01).심공능위Ⅰ、Ⅱ、Ⅲ、Ⅳ급자,기혈청CRP분별위(3.92±0.79)mg/L、(5.03±1.55)me/L、(8.94±2.97)mg/L、(12.21±4.43)mg/L,수방6개월.기중혈청CRP≥10 mg/L자병사솔32.50%(26/83);5 mg/L≤CRP<10 mg/L자,병사솔10.48%(11/109);CRP<5 mg/L자병사솔2.76%(4/150).결론 CHF환자혈청CRP수평승고정도여심력쇠갈엄중정도상평행,병예시환자예후불량.
Objective To determine whether the level of serum C-reactive protein(CLIP) had prognestie val-ue in patients with congestive heart failure(CHF). Methods Serum CRP was measured by enzyme-linked immuno-assay. Results CRP concentration was ( 8.66±4.38 ) mg/L in CHF patients and (1.12±0.87)mg/L in controls( P<0.01). In patients with LVEF ≤35% and > 35%, CRP was ( 11.92±4.55 ) mg/L and ( 5.88±1.92) mg/L( P<0.01 ). In patients with heart function class Ⅰ,Ⅱ,Ⅲ and Ⅳ, CRP was ( 3.92±0.79 ) mg/L, (5.03±1.55 ) mg/L,(8.94±2.97)mg/L, ( 12.21±4.43 ) mg/L, respectively. A negative correlation was observed between serum C RP concentration and LVEF in patients with CHF( r=-0.502,P<0.01 ). According to the concentration of CLIP,83 pa-tients with CRP≥10mg/L had mortality of 32.50% ,109 patients with CRP<10mg/L and ≥5mg/L had mortality of 10.48%,and 150 patients with CRP < 5mg/L had mortality of 2.76%. Conclusion This study shows that serum CRP is increased and has prognostic value in patients with CHF,that the level of CRP is parallel to the severity of CHF.
