中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2011年
9期
800-802
,共3页
于琳%曹爱华%吕孝娜%雷革非
于琳%曹愛華%呂孝娜%雷革非
우림%조애화%려효나%뢰혁비
ABT-724%SHR大鼠%自发活动%认知%非选择性注意力
ABT-724%SHR大鼠%自髮活動%認知%非選擇性註意力
ABT-724%SHR대서%자발활동%인지%비선택성주의력
ABT-724%SHR%Spontaneous locomotor activity%Cognitive ability%Non-selective attention
目的 探讨高选择性多巴胺D4受体激动剂ABT-724对注意缺陷多动障碍(ADHD)动物模型自发性高血压大鼠(SHR)的行为所产生的影响.方法 将哌甲酯(5mg/ks)及三种不同剂量的ABT-724(0.04mg/kg,0.16mg/kg,0.64mg/kg)干预SHR大鼠,并利用开场试验、Morris水迷宫、Làt迷宫对SHR大鼠进行行为学检测,观察SHR大鼠的行为.结果 哌甲酯及ABT-724干预后的SHR大鼠穿越格子数[分别为(70.67±8.59)个,(76.50±10.75)个,(79.17±10.44)个,(65.67±20.62)个]较盐水组大鼠[(130.33±11.40)个]减少,且差异有显著性(P＜0.05)；在Moms水迷宫中,干预后的SHR大鼠空间记忆能力[分别为(52.50±4.04)s,(52.17±2.99)s,(61±8.15)s,(53.83±9.87)s]与盐水组大鼠[(38.83±7.17)s]相比有所提高,差异有统计学意义(P＜0.05)；在Làt迷宫中,干预后的SHR大鼠直立次数[分别为(57.17±5.67)次,(60.83±8.28)次,(55.17±9.45)次,(65.33±9.50)次]与盐水组大鼠[(78.00±13.84)次]相比减少,差异显著(P＜0.05).结论 ABT-724可改善SHR大鼠的自发活动水平、认知功能和非选择性注意力.
目的 探討高選擇性多巴胺D4受體激動劑ABT-724對註意缺陷多動障礙(ADHD)動物模型自髮性高血壓大鼠(SHR)的行為所產生的影響.方法 將哌甲酯(5mg/ks)及三種不同劑量的ABT-724(0.04mg/kg,0.16mg/kg,0.64mg/kg)榦預SHR大鼠,併利用開場試驗、Morris水迷宮、Làt迷宮對SHR大鼠進行行為學檢測,觀察SHR大鼠的行為.結果 哌甲酯及ABT-724榦預後的SHR大鼠穿越格子數[分彆為(70.67±8.59)箇,(76.50±10.75)箇,(79.17±10.44)箇,(65.67±20.62)箇]較鹽水組大鼠[(130.33±11.40)箇]減少,且差異有顯著性(P＜0.05)；在Moms水迷宮中,榦預後的SHR大鼠空間記憶能力[分彆為(52.50±4.04)s,(52.17±2.99)s,(61±8.15)s,(53.83±9.87)s]與鹽水組大鼠[(38.83±7.17)s]相比有所提高,差異有統計學意義(P＜0.05)；在Làt迷宮中,榦預後的SHR大鼠直立次數[分彆為(57.17±5.67)次,(60.83±8.28)次,(55.17±9.45)次,(65.33±9.50)次]與鹽水組大鼠[(78.00±13.84)次]相比減少,差異顯著(P＜0.05).結論 ABT-724可改善SHR大鼠的自髮活動水平、認知功能和非選擇性註意力.
목적 탐토고선택성다파알D4수체격동제ABT-724대주의결함다동장애(ADHD)동물모형자발성고혈압대서(SHR)적행위소산생적영향.방법 장고갑지(5mg/ks)급삼충불동제량적ABT-724(0.04mg/kg,0.16mg/kg,0.64mg/kg)간예SHR대서,병이용개장시험、Morris수미궁、Làt미궁대SHR대서진행행위학검측,관찰SHR대서적행위.결과 고갑지급ABT-724간예후적SHR대서천월격자수[분별위(70.67±8.59)개,(76.50±10.75)개,(79.17±10.44)개,(65.67±20.62)개]교염수조대서[(130.33±11.40)개]감소,차차이유현저성(P＜0.05)；재Moms수미궁중,간예후적SHR대서공간기억능력[분별위(52.50±4.04)s,(52.17±2.99)s,(61±8.15)s,(53.83±9.87)s]여염수조대서[(38.83±7.17)s]상비유소제고,차이유통계학의의(P＜0.05)；재Làt미궁중,간예후적SHR대서직립차수[분별위(57.17±5.67)차,(60.83±8.28)차,(55.17±9.45)차,(65.33±9.50)차]여염수조대서[(78.00±13.84)차]상비감소,차이현저(P＜0.05).결론 ABT-724가개선SHR대서적자발활동수평、인지공능화비선택성주의력.
Objective To investigate the effects of a highly selective dopamine D4 receptor (ABT-724)on behaviors in Spontaneously hypertensive rats (SHR),a rat model of attention-deficit hyperactivity disorder (ADHD).Methods After intervention of methylphenidate(5mg/kg) and three different doses of ABT-724(0.04mg/kg,0.16mg/kg,0.64mg/kg),behaviors of SHR were verified by open-field test,Morris water maze and Làt maze.Results Number of square crossing after intervention of methylphenidate and ABT-724 in SHR( 70.67 ± 8.59,76.50 ± 10.75,79.17 ± 10.44,65.67 ± 20.62) was less than the saline control group( 130.33 ± 1 1.40) (P＜0.05).During Morris water maze,SHRs(52.50 ± 4.04,52.17 ± 2.99,61 ± 8.15,53.83 ± 9.87 ) after intervention of both had a better spatial memory ability than control group(38.83 ±7.17) (P＜0.05).In Làt maze,number of rearing after intervention of both in SHRs(57.17 ± 5.67,60.83 ± 8.28,55.17 ± 9.45,65.33 ± 9.50 ) was less than saline control group(78.00 ± 13.84) (P＜0.05).Conclusion ABT-724 could improve behaviors of spontaneous locomotor activity,cognitive ability,non-selective attention in SHR.
