中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2008年
6期
537-541
,共5页
冯仕庭%孙灿辉%李子平%郭欢仪%彭振鹏%黄剑文%孟悛非%郑可国%许达生
馮仕庭%孫燦輝%李子平%郭歡儀%彭振鵬%黃劍文%孟悛非%鄭可國%許達生
풍사정%손찬휘%리자평%곽환의%팽진붕%황검문%맹전비%정가국%허체생
结直肠肿瘤%体层摄影术,螺旋计算机%灌注%微血管密度%血管内皮生长因子
結直腸腫瘤%體層攝影術,螺鏇計算機%灌註%微血管密度%血管內皮生長因子
결직장종류%체층섭영술,라선계산궤%관주%미혈관밀도%혈관내피생장인자
Colorectal neoplasm%Tomography,X-ray computed%Perfusion%Microvessel density%Vascular endothelial growth factor
目的 探讨结直肠癌64层螺旋CT(64MDCT)灌注成像与微血管密度(MVD)和血管内皮生长因子(VEGF)相关性.方法 对33例结直肠癌患者进行64层螺旋CT灌注成像检查,绘制所选层面靶动脉、靶静脉及肿瘤的感兴趣区(ROI)的时间一密度曲线(TDC).64层螺旋CT灌注的参数包括血流量(BF)、血容量(BV)、平均通过时间(MTT)和表面通透性(PS).测定癌组织的MVD和VEGF的表达.对不同类型TDC间的MVD和VEGF进行比较:并对CT灌注参数与癌组织的MVD和VEGF表达进行相关性分析.结果 结直肠癌组织MVD值为22.61±9.01.VEGF阳性表达率为86.2%(19/25).结直肠癌的TDC分为5种类型,不同TDC类型的MVD和VEGF差异无统计学意义(F值分别为2.59和1.11,P>0.05).CT灌注诸参数与MVD与VEGF均无相关fP>0.05).结论 多层螺旋CT灌注成像与MVD和VEGF均能反映结直肠癌的血管生成状况,但它们之间无相关.
目的 探討結直腸癌64層螺鏇CT(64MDCT)灌註成像與微血管密度(MVD)和血管內皮生長因子(VEGF)相關性.方法 對33例結直腸癌患者進行64層螺鏇CT灌註成像檢查,繪製所選層麵靶動脈、靶靜脈及腫瘤的感興趣區(ROI)的時間一密度麯線(TDC).64層螺鏇CT灌註的參數包括血流量(BF)、血容量(BV)、平均通過時間(MTT)和錶麵通透性(PS).測定癌組織的MVD和VEGF的錶達.對不同類型TDC間的MVD和VEGF進行比較:併對CT灌註參數與癌組織的MVD和VEGF錶達進行相關性分析.結果 結直腸癌組織MVD值為22.61±9.01.VEGF暘性錶達率為86.2%(19/25).結直腸癌的TDC分為5種類型,不同TDC類型的MVD和VEGF差異無統計學意義(F值分彆為2.59和1.11,P>0.05).CT灌註諸參數與MVD與VEGF均無相關fP>0.05).結論 多層螺鏇CT灌註成像與MVD和VEGF均能反映結直腸癌的血管生成狀況,但它們之間無相關.
목적 탐토결직장암64층라선CT(64MDCT)관주성상여미혈관밀도(MVD)화혈관내피생장인자(VEGF)상관성.방법 대33례결직장암환자진행64층라선CT관주성상검사,회제소선층면파동맥、파정맥급종류적감흥취구(ROI)적시간일밀도곡선(TDC).64층라선CT관주적삼수포괄혈류량(BF)、혈용량(BV)、평균통과시간(MTT)화표면통투성(PS).측정암조직적MVD화VEGF적표체.대불동류형TDC간적MVD화VEGF진행비교:병대CT관주삼수여암조직적MVD화VEGF표체진행상관성분석.결과 결직장암조직MVD치위22.61±9.01.VEGF양성표체솔위86.2%(19/25).결직장암적TDC분위5충류형,불동TDC류형적MVD화VEGF차이무통계학의의(F치분별위2.59화1.11,P>0.05).CT관주제삼수여MVD여VEGF균무상관fP>0.05).결론 다층라선CT관주성상여MVD화VEGF균능반영결직장암적혈관생성상황,단타문지간무상관.
Objective To evaluate the correlation of 64-multidetector-row CT (64MDCT) perfusion imaging with microvessel density(MVD)and vascular endothelial growth factor(VEGF)in colorectal carcinoma. Methods 64MDCT perfusion imaging was performed in 33 patients with pathologically verified coiorectal carcinoma. Time-density curves(TDC) were created from the region of interest (ROI) drawn over the tumor, target artery and vein by 64MDCT with perfusion functional software. The individual perfusion maps generated were for blood flow(BF), blood volume (BV), mean transit time (MTT) and permeability-surface area product(PS). MVD and VEGF expression of surgical specimens were examined by immunohistochemical staining with anti-CD34, anti-VEGF monoclonal antibody. MVD and VEGF were compared among the different types of TDC in colorectal carcinoma. The correlation of CT perfusion parameters with MVD and VEGF was also examined. Results TDC of colorectal carcinoma was divided into five types according to their shapes. MVD in the colorectal carcinoma was 22.61±9.01. VEGF staining was found in 25 of 29 tumors (86.2%). The score of VEGF expression was 4.15±1.09. No significant differences of MVD and VEGF expression among TDC types were found (F=2.59, 1.11, P>0.05). There were also no correlations of MVD and VEGF expression with any dynamic CT parameters(P>0.05). Conclusion 64MDCT perfusion imaging, MVD and VEGF may reflect angiogenic activity, but no significant correlations are found among them.