国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2011年
9期
674-676
,共3页
乳腺肿瘤%信号传导%基因LKB1
乳腺腫瘤%信號傳導%基因LKB1
유선종류%신호전도%기인LKB1
Breast neoplasms%Signal transduction%Genes,LKB1
Hedgehog信号通路在乳腺癌中过度激活,LKB1是抑癌基因,有抑制乳腺癌增殖的功能.LKB1过表达可调控Hedgehog信号通路的靶基因CyclinD1系列基因的表达,同时研究发现Hedgehog信号通路中PKA基因起重要作用,其激活与cAMP状态有关,而LKB1基因能影响cAMP的状态.因此,LKB1基因与Hedgehog信号通路可能存在某种必然的联系.
Hedgehog信號通路在乳腺癌中過度激活,LKB1是抑癌基因,有抑製乳腺癌增殖的功能.LKB1過錶達可調控Hedgehog信號通路的靶基因CyclinD1繫列基因的錶達,同時研究髮現Hedgehog信號通路中PKA基因起重要作用,其激活與cAMP狀態有關,而LKB1基因能影響cAMP的狀態.因此,LKB1基因與Hedgehog信號通路可能存在某種必然的聯繫.
Hedgehog신호통로재유선암중과도격활,LKB1시억암기인,유억제유선암증식적공능.LKB1과표체가조공Hedgehog신호통로적파기인CyclinD1계렬기인적표체,동시연구발현Hedgehog신호통로중PKA기인기중요작용,기격활여cAMP상태유관,이LKB1기인능영향cAMP적상태.인차,LKB1기인여Hedgehog신호통로가능존재모충필연적련계.
Hedgehog signaling pathway is excessive activated in breast cancer.LKBl is currently accepted as a tumor-suppressor gene,which can inhibit the proliferation of breast cancer.The overexpression of LKB1 can regulate the expression of CyclinDl series gene which is a target gene of Hedgehog signaling pathway.Meanwhile,the study found that PKA gene play an important role in Hedgehog signaling pathway,its activation is related with the cAMP state,and LKB1 genes can influence the cAMP state.Therefore,LKB1 gene and the Hedgehog signaling pathway may exist some inevitable connection.
