中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2011年
4期
322-324
,共3页
张爱霞%李素萍%张红玲%康春松%刘春%杨春霞%刘玮玮%尤晓霞%张克让%杜永成
張愛霞%李素萍%張紅玲%康春鬆%劉春%楊春霞%劉瑋瑋%尤曉霞%張剋讓%杜永成
장애하%리소평%장홍령%강춘송%류춘%양춘하%류위위%우효하%장극양%두영성
应激%脑电超慢涨落图%神经递质
應激%腦電超慢漲落圖%神經遞質
응격%뇌전초만창락도%신경체질
Stress%Encephalofluctuogram%Neurotransmitters
目的 用脑电超慢涨落图分析仪(ET)在无创条件下观察应激事件后人体脑神经递质活动情况.方法 用脑电超慢涨落图分析仪提取在脑电中载有脑神经递质调节系统的震荡信息(即S谱线),分析应激事件后人体脑神经递质的活动情况,同时用创伤性应激障碍检查量表平民版(PCL-C)评估其临床症状.结果 ①与期望值(数据单位均为相对值)对照:γ-氨基丁酸(GABA)[(4.64±2.88),(8.45±0.42),P＜0.01]活动降低、乙酰胆碱(Ach)[(17.01±7.41),(14.95±0.65),P＜0.05]、多巴胺(DA)[(17.01±7.41),(7.59±0.55),P＜0.01],去甲肾上腺素(NE)[(13.07±4.33),(11.82±0.84),P＜0.05]活动增高.②可疑创伤性应激障碍与非创伤性应激障碍脑神经递质比较:GABA活动变化显著(t=6.902,P＜0.01).③PCL-C再体验分量表评分与GABA活动呈显著负相关(r=-0.777,P＜0.01),与DA活动呈显著正相关(r=0.360,P＜0.01),高警觉分量表评分同NE活动成正相关(r=0.221,P＜0.05),逃避/麻木分量表与谷氨酸(Glu)活动成负相关(r=-0.274,P＜0.05).结论 应激事件后人体脑神经递质活动发生异常,可能参与了应激反应症状的产生.
目的 用腦電超慢漲落圖分析儀(ET)在無創條件下觀察應激事件後人體腦神經遞質活動情況.方法 用腦電超慢漲落圖分析儀提取在腦電中載有腦神經遞質調節繫統的震盪信息(即S譜線),分析應激事件後人體腦神經遞質的活動情況,同時用創傷性應激障礙檢查量錶平民版(PCL-C)評估其臨床癥狀.結果 ①與期望值(數據單位均為相對值)對照:γ-氨基丁痠(GABA)[(4.64±2.88),(8.45±0.42),P＜0.01]活動降低、乙酰膽堿(Ach)[(17.01±7.41),(14.95±0.65),P＜0.05]、多巴胺(DA)[(17.01±7.41),(7.59±0.55),P＜0.01],去甲腎上腺素(NE)[(13.07±4.33),(11.82±0.84),P＜0.05]活動增高.②可疑創傷性應激障礙與非創傷性應激障礙腦神經遞質比較:GABA活動變化顯著(t=6.902,P＜0.01).③PCL-C再體驗分量錶評分與GABA活動呈顯著負相關(r=-0.777,P＜0.01),與DA活動呈顯著正相關(r=0.360,P＜0.01),高警覺分量錶評分同NE活動成正相關(r=0.221,P＜0.05),逃避/痳木分量錶與穀氨痠(Glu)活動成負相關(r=-0.274,P＜0.05).結論 應激事件後人體腦神經遞質活動髮生異常,可能參與瞭應激反應癥狀的產生.
목적 용뇌전초만창락도분석의(ET)재무창조건하관찰응격사건후인체뇌신경체질활동정황.방법 용뇌전초만창락도분석의제취재뇌전중재유뇌신경체질조절계통적진탕신식(즉S보선),분석응격사건후인체뇌신경체질적활동정황,동시용창상성응격장애검사량표평민판(PCL-C)평고기림상증상.결과 ①여기망치(수거단위균위상대치)대조:γ-안기정산(GABA)[(4.64±2.88),(8.45±0.42),P＜0.01]활동강저、을선담감(Ach)[(17.01±7.41),(14.95±0.65),P＜0.05]、다파알(DA)[(17.01±7.41),(7.59±0.55),P＜0.01],거갑신상선소(NE)[(13.07±4.33),(11.82±0.84),P＜0.05]활동증고.②가의창상성응격장애여비창상성응격장애뇌신경체질비교:GABA활동변화현저(t=6.902,P＜0.01).③PCL-C재체험분량표평분여GABA활동정현저부상관(r=-0.777,P＜0.01),여DA활동정현저정상관(r=0.360,P＜0.01),고경각분량표평분동NE활동성정상관(r=0.221,P＜0.05),도피/마목분량표여곡안산(Glu)활동성부상관(r=-0.274,P＜0.05).결론 응격사건후인체뇌신경체질활동발생이상,가능삼여료응격반응증상적산생.
Objective To investigate the change characteristics of the brain neurotransmitters of human with stress events by the Encephaloflucgram technology (ET) at the noninvasive condition. Methods Extract shocking informations with neurotransmitter requlation systems in EEG ( S spectral line) by ET and analyze thechange characteristics of the brain neurotransmitters of human with stress events, the clincial symptons of the patients were evaluated by the post-traumatic stress disorder-check scale (PCL-C). Results ①Compared with expected number,the activity of neurotransmitters such as γ-aminobutyric acid (GABA) were significantly decreased (4.64 ±2.88,8.45 ±0.42, P＜0. 01 ) and the activity of neurotransmitters such as dopamine( DA ) ( 17.01 ±7.41,7.59±0.55, P＜0. 01),acetylcholine(Ach) (17.01 ±7.41,14.95 ±0.65, P＜0.05) ,norepinephrine (NE ) ( 13.07 ± 4.33,11.82 ± 0.84, P ＜ 0. 05 ) were increased. ②There was a significant difference on GABA ( t =6.902, P ＜ 0. 01 ) between suspect of post-traumatic stress disorder and non-post-traumatic stress disorder. ③In PCL-C scale score, intrusion factor had negative correlation to the activity of GABA ( r = - 0.777, P ＜ 0.01 ), and positive correlation to the activity of DA ( r = 0.360, P ＜ 0.01 ), hyper-arousal factor was positive correlated with the activity of NE ( r=0.221, P＜0.05) ,escaping/numbness factor was negative correlated with the activity ofGlu( r= -0.274, P＜0.05). Conclusion In traumatic stress events GABA,Ach,DA,NE neurotransmitters aresignificantly changed ,and meybe participat stress responses.
