中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
2期
13-15
,共3页
胃癌%Claudin-1%Id-1%Id-3%免疫组化
胃癌%Claudin-1%Id-1%Id-3%免疫組化
위암%Claudin-1%Id-1%Id-3%면역조화
Gastric carcinoma%Claudin-1%Id-1%Id-3%Immunohistochemistry
目的 研究胃癌组织Claudin-1、Id-1、Id-3表达与胃癌细胞分化、增殖、侵袭转移和预后的关系.方法 应用免疫组织化学检测Claudin-1、Id-1、Id3-蛋白在胃癌组织中的表达.结果 Claudin-1表达水平与胃癌组织学类型、肿瘤侵袭程度及淋巴结转移相关(P<0.05),Id-1蛋白表达与胃癌淋巴结转移呈负相关(P<0.05);Id-3蛋白表达在不同组织起源的胃癌之间差异有统计学意义(P<0.05);Claudin-1作为细胞间紧密连接的构成成份在胃癌组织中的表达作用与Id蛋白表达正相关.结论 Claudin-1表达上调以及在胃癌侵袭过程中表达转化提示参与肿瘤的生物学行为的转化;Id-1在胃癌淋巴结转移的预测中有一定的应用价值;不同组织起源的胃癌Id-3呈差异性表达;Clandin及Id蛋白在胃癌的侵袭转移及临床治疗及预后判断有一定的应用价值.
目的 研究胃癌組織Claudin-1、Id-1、Id-3錶達與胃癌細胞分化、增殖、侵襲轉移和預後的關繫.方法 應用免疫組織化學檢測Claudin-1、Id-1、Id3-蛋白在胃癌組織中的錶達.結果 Claudin-1錶達水平與胃癌組織學類型、腫瘤侵襲程度及淋巴結轉移相關(P<0.05),Id-1蛋白錶達與胃癌淋巴結轉移呈負相關(P<0.05);Id-3蛋白錶達在不同組織起源的胃癌之間差異有統計學意義(P<0.05);Claudin-1作為細胞間緊密連接的構成成份在胃癌組織中的錶達作用與Id蛋白錶達正相關.結論 Claudin-1錶達上調以及在胃癌侵襲過程中錶達轉化提示參與腫瘤的生物學行為的轉化;Id-1在胃癌淋巴結轉移的預測中有一定的應用價值;不同組織起源的胃癌Id-3呈差異性錶達;Clandin及Id蛋白在胃癌的侵襲轉移及臨床治療及預後判斷有一定的應用價值.
목적 연구위암조직Claudin-1、Id-1、Id-3표체여위암세포분화、증식、침습전이화예후적관계.방법 응용면역조직화학검측Claudin-1、Id-1、Id3-단백재위암조직중적표체.결과 Claudin-1표체수평여위암조직학류형、종류침습정도급림파결전이상관(P<0.05),Id-1단백표체여위암림파결전이정부상관(P<0.05);Id-3단백표체재불동조직기원적위암지간차이유통계학의의(P<0.05);Claudin-1작위세포간긴밀련접적구성성빈재위암조직중적표체작용여Id단백표체정상관.결론 Claudin-1표체상조이급재위암침습과정중표체전화제시삼여종류적생물학행위적전화;Id-1재위암림파결전이적예측중유일정적응용개치;불동조직기원적위암Id-3정차이성표체;Clandin급Id단백재위암적침습전이급림상치료급예후판단유일정적응용개치.
Objective To investigate the relationship of the expression of Ciaudin-1, Id-1, Id-3 and gastric carcinoma cell differentiation, proliferation, invasion and metastasis and prognosis. Methods By using Envision immunohistochemistry detected the expression of Claudin-1, IdA, Id3-protein in gastric carcinoma. Re-sults Claudin-1 expression was correlated with the histological type of gastric carcinoma, the extent of tumor in-vasion and lymph node metastasis (P < 0.05), Id-1 protein expression in gastric carcinoma with lymph node neg-ative correlation(P <0. 05); the difference of Id-3 protein expression in different organization original gastric carcinoma was statistically significant (P < 0. 05) ; the expressed effect of Claudin-1 cells as close connection composition in gastric carcinoma tissue was direct correlated to the Id protein expression. Conclusion The up-regulation of Claudin-1 expression and their expression transformation in the process of gastric carcinoma inva-sion prompted they participated in the transformation of tumor biological behaviour; Id-1 in the forecast of lymph node metastasis in gastric carcinoma had utilized utilized value, Id-3 in different organization original gastric car-cinoma expressed difference, Clandin and Id protein in gastric carcinoma invasion metastasis and clinical treat-ment and prognosis criterion had certain utilized value.
