CAJ | 학술논문

将473例肌酐正常的2型糖尿病肾病(DN)患者根据尿白蛋白/肌酐分为微量白蛋白尿组(DNI组,246例)和大量白蛋白尿组(DN2组,227例),结果显示,DN2组WBC、单核细胞、CRP 较DNI组显著增加[(6.8±1.7)×109/L比(6.3±1.5)×109/L,(0.49 ±0.23)×109/L比(0.32±0.21)×109/L,(4.1±1.1 )mg/L比(1.7±0.3)mg/L,均P＜0.05].多元线性回归分析显示,WBC、单核细胞、LDL-C和淋巴细胞是尿白蛋白/肌酐升高的独立影响因素.
장473례기항정상적2형당뇨병신병(DN)환자근거뇨백단백/기항분위미량백단백뇨조(DNI조,246례)화대량백단백뇨조(DN2조,227례),결과현시,DN2조WBC、단핵세포、CRP 교DNI조현저증가[(6.8±1.7)×109/L비(6.3±1.5)×109/L,(0.49 ±0.23)×109/L비(0.32±0.21)×109/L,(4.1±1.1 )mg/L비(1.7±0.3)mg/L,균P＜0.05].다원선성회귀분석현시,WBC、단핵세포、LDL-C화림파세포시뇨백단백/기항승고적독립영향인소.
A total of 473 patients of diabetic nephropathy (DN) with normal serum creatinine were recruited.Blood routine,blood lipids and urine albumin/creatinine ratio (UACR) were measured.They were divided into microalbuminuria group (DN1,n =246 ) and macroalbuminuria group (DN2,n =227 ).The white blood cell (WBC) count,monocyte count and CRP significantly increased with the progression of DN in the DN2 group versus those in the DNI group [ (6.8 ± 1.7 ) × 109/L vs.(6.3 ± 1.5 ) × 109/L,(0.49±0.23) ×109/Lvs.(0.32 ±0.21) ×109/L,(4.1 ±1.1)mg/Lvs.(1.7±0.3) mg/L,all P＜ 0.05].According to multiple linear regression analysis,WBC,monocyte,low density lipoproteincholesterol and lymphocyte were found to be independent influencing factors for the elevation of UACR.