中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2011年
4期
257-260
,共4页
王枫%王璟%赵永波%陈维杰%郭春妮%赵圣杰
王楓%王璟%趙永波%陳維傑%郭春妮%趙聖傑
왕풍%왕경%조영파%진유걸%곽춘니%조골걸
阿尔茨海默病%认知障碍%本体感觉
阿爾茨海默病%認知障礙%本體感覺
아이자해묵병%인지장애%본체감각
Alzheimer disease%Cognition disorders%Proprioception
目的 探讨遗忘型轻度认知功能障碍(amnestic mild cognitive impairment,aMCI)和轻中度阿尔茨海默(Alzheimer's disease,AD)患者的平衡功能变化,以及人体姿势平衡仪在鉴别aMCI、轻中度AD以及健康人群中的应用价值.方法 应用人体姿势平衡仪对20例aMCI和20例轻中度AD患者的平衡功能进行测试,并选取20名年龄性别相匹配的健康体检者作为对照.结果 轻中度AD患者的所有平衡仪检测指标均与健康对照有显著差异,其中AD组支撑面积(15 398±926)mm2,睁眼状态时X轴平均位移(Mean X,10.2±4.1)mm、Y轴平均位移(Mean Y,-29.8±10.2)mm、X轴最大值(Max X,30.5±9.5)mm、Y轴最大值(Max Y,42.7±11.4)mm、姿势图长度(LSKG,528.4±105.4)mm、姿势图面积(SSKG,252.5±89.7)mm2,闭眼状态时Mean X(13.1±4.5)mm、Mean Y(-58.2±16.9)mm、Max X(37.7±10.5)mm、Max Y(78.5±18.7)mm、LSKG(816.6±171.3)mm、SSKG(649.0±129.7)mm2,与健康对照组各指标[支撑面积(31 654±2132)mm2,睁眼状态时分别为(5.8±1.4)mm、(-14.9±4.4)mm、(18.3±4.1)mm、(23.3±6.8)mm、(390.3±68.4)mm、(178.8±40.9)mm2;闭眼状态时(7.9±1.5)mm、(-25.6±5.4)mm、(24.7±7.3)mm、(39.9±9.9)mm、(533.5±97.4)mm、(290.5±73.3)mm2]比较差异均有统计学意义(支撑面积t=8.57,睁眼状态时F值分别为17.41、38.10、60.46、102.10、29.31、27.85,闭眼状态时F值分别为37.20、541.79、34.51、185.56、122.83、384.27,均P＜0.05);支撑面积和Mean Y在aMCI组[(23 921±1637)mm2,(-39.8±8.6)mm]和健康对照组[(31 654±2132)mm2,(-25.6±5.4)mm]之间差异有统计学意义(t=6.50,P=0.038;t=-15.34,P=0.012).结论 轻中度AD及aMCI患者均存在平衡功能障碍,人体姿势平衡仪检测对临床上运动表现和平衡能力均在正常范围的aMCI、轻中度AD以及健康人群具有鉴别意义.
目的 探討遺忘型輕度認知功能障礙(amnestic mild cognitive impairment,aMCI)和輕中度阿爾茨海默(Alzheimer's disease,AD)患者的平衡功能變化,以及人體姿勢平衡儀在鑒彆aMCI、輕中度AD以及健康人群中的應用價值.方法 應用人體姿勢平衡儀對20例aMCI和20例輕中度AD患者的平衡功能進行測試,併選取20名年齡性彆相匹配的健康體檢者作為對照.結果 輕中度AD患者的所有平衡儀檢測指標均與健康對照有顯著差異,其中AD組支撐麵積(15 398±926)mm2,睜眼狀態時X軸平均位移(Mean X,10.2±4.1)mm、Y軸平均位移(Mean Y,-29.8±10.2)mm、X軸最大值(Max X,30.5±9.5)mm、Y軸最大值(Max Y,42.7±11.4)mm、姿勢圖長度(LSKG,528.4±105.4)mm、姿勢圖麵積(SSKG,252.5±89.7)mm2,閉眼狀態時Mean X(13.1±4.5)mm、Mean Y(-58.2±16.9)mm、Max X(37.7±10.5)mm、Max Y(78.5±18.7)mm、LSKG(816.6±171.3)mm、SSKG(649.0±129.7)mm2,與健康對照組各指標[支撐麵積(31 654±2132)mm2,睜眼狀態時分彆為(5.8±1.4)mm、(-14.9±4.4)mm、(18.3±4.1)mm、(23.3±6.8)mm、(390.3±68.4)mm、(178.8±40.9)mm2;閉眼狀態時(7.9±1.5)mm、(-25.6±5.4)mm、(24.7±7.3)mm、(39.9±9.9)mm、(533.5±97.4)mm、(290.5±73.3)mm2]比較差異均有統計學意義(支撐麵積t=8.57,睜眼狀態時F值分彆為17.41、38.10、60.46、102.10、29.31、27.85,閉眼狀態時F值分彆為37.20、541.79、34.51、185.56、122.83、384.27,均P＜0.05);支撐麵積和Mean Y在aMCI組[(23 921±1637)mm2,(-39.8±8.6)mm]和健康對照組[(31 654±2132)mm2,(-25.6±5.4)mm]之間差異有統計學意義(t=6.50,P=0.038;t=-15.34,P=0.012).結論 輕中度AD及aMCI患者均存在平衡功能障礙,人體姿勢平衡儀檢測對臨床上運動錶現和平衡能力均在正常範圍的aMCI、輕中度AD以及健康人群具有鑒彆意義.
목적 탐토유망형경도인지공능장애(amnestic mild cognitive impairment,aMCI)화경중도아이자해묵(Alzheimer's disease,AD)환자적평형공능변화,이급인체자세평형의재감별aMCI、경중도AD이급건강인군중적응용개치.방법 응용인체자세평형의대20례aMCI화20례경중도AD환자적평형공능진행측시,병선취20명년령성별상필배적건강체검자작위대조.결과 경중도AD환자적소유평형의검측지표균여건강대조유현저차이,기중AD조지탱면적(15 398±926)mm2,정안상태시X축평균위이(Mean X,10.2±4.1)mm、Y축평균위이(Mean Y,-29.8±10.2)mm、X축최대치(Max X,30.5±9.5)mm、Y축최대치(Max Y,42.7±11.4)mm、자세도장도(LSKG,528.4±105.4)mm、자세도면적(SSKG,252.5±89.7)mm2,폐안상태시Mean X(13.1±4.5)mm、Mean Y(-58.2±16.9)mm、Max X(37.7±10.5)mm、Max Y(78.5±18.7)mm、LSKG(816.6±171.3)mm、SSKG(649.0±129.7)mm2,여건강대조조각지표[지탱면적(31 654±2132)mm2,정안상태시분별위(5.8±1.4)mm、(-14.9±4.4)mm、(18.3±4.1)mm、(23.3±6.8)mm、(390.3±68.4)mm、(178.8±40.9)mm2;폐안상태시(7.9±1.5)mm、(-25.6±5.4)mm、(24.7±7.3)mm、(39.9±9.9)mm、(533.5±97.4)mm、(290.5±73.3)mm2]비교차이균유통계학의의(지탱면적t=8.57,정안상태시F치분별위17.41、38.10、60.46、102.10、29.31、27.85,폐안상태시F치분별위37.20、541.79、34.51、185.56、122.83、384.27,균P＜0.05);지탱면적화Mean Y재aMCI조[(23 921±1637)mm2,(-39.8±8.6)mm]화건강대조조[(31 654±2132)mm2,(-25.6±5.4)mm]지간차이유통계학의의(t=6.50,P=0.038;t=-15.34,P=0.012).결론 경중도AD급aMCI환자균존재평형공능장애,인체자세평형의검측대림상상운동표현화평형능력균재정상범위적aMCI、경중도AD이급건강인군구유감별의의.
Objective To investigate alterations of balance function in patients with mild-moderate Alzheimer's disease (AD) and with amnestic mild cognitive impairment (aMCI),and the possibility of using posturography to differentiate aMCI,mild-moderate AD and normal subjects. Methods The balance function of 20 patients with mild-moderate AD and 20 patients with aMCI were evaluated by posturography,and 20 healthy subjects of the same age range were recruited as controls.Results All posturography measures were significantly altered in mild-moderate AD patients compared with normal controls,with limits of stability( ( 15 398 ± 926 ) mm2 vs ( 31 654 ± 2132 ) mm2 ),open-eyed Mean X ( ( 10. 2 ± 4. 1 ) mm vs (5.8 ± 1. 4)mm) ,Mean Y(( -29.8 ± 10.2)mm vs ( -14.9 ±4.4) mm),Max X((30.5 ±9.5)mm vs (18.3 ±4. 1)mm ),Max Y((42.7 ± 11.4)mm vs (23.3 ±6.8)mm),LSKG((528.4 ± 105.4)mm vs (390. 3 ± 68.4 ) mm ),SSKG ( ( 252. 5 ± 89. 7 ) mm2 vs ( 178.8 ± 40. 9 ) mm2 ),close-eyed Mean X ((13. 1 ±4. 5) mm vs (7.9 ± 1.5)mm) ,Mean Y (( -58.2 ± 16. 9) mm vs ( -25.6 ±5.4) mm) ,Max X ((37.7±10.5)mm vs (24.7 ±7.3) mm ),Max Y ((78.5±18.7)mm vs (39.9 ±9.9) mm),LSKG ((816.6±171.3) mm vs (533.5 ±97.4) mm),SSKG((649.0 ± 129.7) mm2 vs (290.5 ±73.3) mm2),respectively ( t = 8.57; open-eyed F = 17.41,38. 10,60. 46,102. 10,29. 31,27. 85; close-eyed F = 37.20,541.79,34. 51,185.56,122. 83,384. 27 ;all P ＜0. 05) ;limits of stability ( (23 921 ± 1637 )mm2 vs (31 654 ±2132 ) mm2 ) and mean Y ( Antero-posterior sway,( - 39. 8 ± 8. 6 ) mm vs ( - 25.6±5.4 ) mm) were the only parameters which discriminated between aMCI and normal controls,respectively ( t = 6. 50,P = 0. 038; t =- 15.34,P = 0. 012). Conclusions Impairment in balance is a feature not only of mild-moderate AD,but also of aMCI,and posturography may be used as a possible test in differentiating between normal subjects,patients with aMCI and patients with mild-moderate AD whose motor performance and balance features are otherwise clinically normal,limits of stability and mean Y are the most sensitive parameters.
