CAJ | 학술논문

目的探讨5-羟色胺综合征的临床特点并观察其治疗效果. 方法回顾性分析盐城市第一人民医院神经内科自2006年1月至2011年12月收治的15例5-羟色胺综合征患者(根据症状轻重分为轻度9例,中度5例,重度1例)的临床特征,经停用5-羟色胺能药物及予赛庚啶和支持治疗后分析其疗效. 结果患者临床表现多样化:易激惹4例;心动过速12例,肠鸣音亢进5例,腹泻4例,出汗12例,发热5例,高血压6例；眼震4例,瞳孔扩大4例,肌肉震颤6例,肌张力增高8例,肌阵挛4例,腱反射亢进8例,共济失调2例,痫性发作2例.9例轻度患者均在72h内症状缓解；5例中度及1例重度患者中症状持续时间最长者126 h,平均治疗时间(86.9±21.7)h. 结论 5-羟色胺综合征临床表现主要为精神状态的改变、自主神经功能异常、神经肌肉的过度兴奋.其防治在于早期发现、适当治疗及临床医生对5-羟色胺能药物副作用的认识.
목적 탐토5-간색알종합정적림상특점병관찰기치료효과. 방법 회고성분석염성시제일인민의원신경내과자2006년1월지2011년12월수치적15례5-간색알종합정환자(근거증상경중분위경도9례,중도5례,중도1례)적림상특정,경정용5-간색알능약물급여새경정화지지치료후분석기료효. 결과 환자림상표현다양화:역격야4례;심동과속12례,장명음항진5례,복사4례,출한12례,발열5례,고혈압6례；안진4례,동공확대4례,기육진전6례,기장력증고8례,기진련4례,건반사항진8례,공제실조2례,간성발작2례.9례경도환자균재72h내증상완해；5례중도급1례중도환자중증상지속시간최장자126 h,평균치료시간(86.9±21.7)h. 결론 5-간색알종합정림상표현주요위정신상태적개변、자주신경공능이상、신경기육적과도흥강.기방치재우조기발현、괄당치료급림상의생대5-간색알능약물부작용적인식.
Objective To investigate the clinical features of serotonin syndrome (SS) and observe its curative effects. Methods Retrospective analysis was performed on the clinical features of 15 patients with SS admitted to our hospital from January 2006 to December 2011; 9 mild-ill cases,5 moderately-ill cases,and 1 severe-ill case were noted in these patients.After the serotonin drugs were removed and cyproheptadine and supportive treatment were given, curative effects were analyzed.Results The clinical manifestations of SS were highly variable: irritability was noted in 4 patients,tachyrhythmia in 12,hyperactive bowel sounds in 5,diarrhea in 4,diaphorisis in 12,febricity in 5,hypertension in 6,ocular ataxia in 4, mydfiasis in 4, musculature tremor in 6, hypermyotonia in 8,myoclonus in 4,tendon hyperreflexia in 8,ataxia in 2 and seizure attack in 2.The symptoms of 9 mild-ill cases were recovered within 72 h.The major of duration of symptoms was 126 h and the mean time of therapy was (86.9±21.7) h in 5 moderate-ill cases and 1 severe-ill case. Conclusion SS is characterized by mental status changes,autonomic instability,and neuromuscular hyperactivity.The key point of prevention and cure is early diagnosis,appropriate management and being early aware of the serotonergic drug side effect by clinicians.