CYP2D6基因多态性与乳腺癌内分泌治疗
CYP2D6기인다태성여유선암내분비치료
Progress on the relationship between genetic polymorphism of CYP2D6 and endocrine therapy of breast cancer
  • 万方数据
    中国癌症杂志 중국암증잡지
    CHINA ONCOLOGY
    2009年 12期 959-962 ,共4页

    张萍%顾史洋%覃文新%胡夕春

    장평%고사양%담문신%호석춘

    CYP2D6%遗传多态性%他莫昔芬代谢%内分泌治疗%乳腺癌 CYP2D6%遺傳多態性%他莫昔芬代謝%內分泌治療%乳腺癌
    CYP2D6%유전다태성%타막석분대사%내분비치료%유선암
    CYP 2D6%genetic polymorphism%tamoxifen metabolism%endocrine therapy%breast cancer
    CYP2D6是细胞色素P450的一种同工酶,代谢许多临床常用药物.其基因的多态性可以影响他莫昔芬的代谢,从而导致携带不同基因型的乳腺癌患者对他莫昔芬的反应性不同.本文简要综述了CYP2D6基因多态性与他莫昔芬代谢和疗效的关系,药物间的相互作用对他莫昔芬代谢的影响,以及针对不同患者选择个体化内分泌治疗方案.
    CYP2D6시세포색소P450적일충동공매,대사허다림상상용약물.기기인적다태성가이영향타막석분적대사,종이도치휴대불동기인형적유선암환자대타막석분적반응성불동.본문간요종술료CYP2D6기인다태성여타막석분대사화료효적관계,약물간적상호작용대타막석분대사적영향,이급침대불동환자선택개체화내분비치료방안.
    CYP2D6 is one of the cytochrome P450 isozymes which are involved in the metabolism of various drugs with wide use. Polymorphism at the CYP2D6 locus is one of the most widely known causes for pharmacogenetic variability in humans beings. This review focuses on the importance of CYP2D6 polymorphism in the metabolism of tamoxifen, relationships between the genetic polymorphism and prognosis of patients who have underwent endocrine therapy, and evidences indicating that CYP2D6 may be used as a predictive marker for choosing optimal endocrine therapy for patients with breast cancer.
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