CAJ | 학술논문

目的探讨并比较关节腔内注射玻璃酸钠与二丙酸倍他米松/倍他米松磷酸二钠(得宝松)治疗膝骨性关节炎的临床疗效.方法选择诊断明确的膝骨性关节炎患者94例,随机分为HA组和Corticosteroid组,HA组患膝关节腔内注射玻璃酸钠2.5 ml,每周1次,5次为1疗程;Corticosteroid组于1、4周关节腔内注入得宝松1 ml.在治疗前、治疗4周和12周记录疼痛、肿胀改善程度及Lequesne膝关节功能评分.结果 88例患者获得3个月随访.在治疗4周时两组均能明显缓解疼痛及改善膝关节功能,两组间相比差别无统计学意义;在治疗12周时疼痛及膝关节功能评分均显示HA组优于Corticosteroid组.结论关节腔内注射玻璃酸钠与得宝松治疗膝骨性关节炎均能获得良好的近期临床疗效,相比之下,玻璃酸钠注射具有更持久的长期效果.
목적 탐토병비교관절강내주사파리산납여이병산배타미송/배타미송린산이납(득보송)치료슬골성관절염적림상료효.방법 선택진단명학적슬골성관절염환자94례,수궤분위HA조화Corticosteroid조,HA조환슬관절강내주사파리산납2.5 ml,매주1차,5차위1료정;Corticosteroid조우1、4주관절강내주입득보송1 ml.재치료전、치료4주화12주기록동통、종창개선정도급Lequesne슬관절공능평분.결과 88례환자획득3개월수방.재치료4주시량조균능명현완해동통급개선슬관절공능,량조간상비차별무통계학의의;재치료12주시동통급슬관절공능평분균현시HA조우우Corticosteroid조.결론 관절강내주사파리산납여득보송치료슬골성관절염균능획득량호적근기림상료효,상비지하,파리산납주사구유경지구적장기효과.
Objective To investigate and compare the clinical effects of intraarticular injection of sodium hyaluronate and diprospan on knee osteoarthritis. Methods 94 patients with knee osteoarthritis were divided into two groups, the HA group and Cortieosteroid group. Each patient in the HA group was treated with intra-articular injection of sodium hyaluronate at 2.5 ml every week for 5 weeks, and each patient in the Corticosteroid group was treated with intra-articular injection of diprospan at 1ml on the first and fourth week. The clinical assessments included pain,joint effusion,and Lequesne Index. Assessments were done at baseline, at week 4, and week 12. Results 88 cases were followed up for 3 months. A significant decrease in VAS scores for pain and in Lequesne Index was found in both groups at week 4 when compared to baseline and there were no significant differences between the two groups. However,at 12 week improvement in pain score and Lequesne Index was found in favour of hyaluronic acid. In addition,diprospan seemed to have preferable short-term effect on patient with joint effusion. Conclusion Both intra-articular injection of sodium hyaluronate and diprospan provided clinically significant improvement in short-term and demonstrated that hyaluronic acid had a more long-term beneficial effect in patients with knee osteoarthritis.