CAJ | 학술논문

目的探讨左旋西替利嗪对咳嗽变异性哮喘患者血清白细胞介素13(IL-13.)与白细胞介素18(IL-18)的影响.方法 70例咳嗽变异性哮喘患者随机分为35例用左旋西替利嗪治疗的治疗组,35例用氯苯那敏治疗的对照组.检测治疗前后IL-13与IL-18的变化.结果治疗组治疗后患者的咳嗽评分有明显改善.治疗组治疗后IL-13与IL-18分别为(46.7±17.3)ng/L和(145.2±27.1)ng/L,对照组分别为(98.5±30.7)ng/L和(179.6±30.5)ng/L,两组比较差异有统计学意义(P＜0.01).结论左旋西替利嗪可能通过改善IL-13与IL-18而改善咳嗽变异性哮喘患者的病情.
목적 탐토좌선서체리진대해수변이성효천환자혈청백세포개소13(IL-13.)여백세포개소18(IL-18)적영향.방법 70례해수변이성효천환자수궤분위35례용좌선서체리진치료적치료조,35례용록분나민치료적대조조.검측치료전후IL-13여IL-18적변화.결과 치료조치료후환자적해수평분유명현개선.치료조치료후IL-13여IL-18분별위(46.7±17.3)ng/L화(145.2±27.1)ng/L,대조조분별위(98.5±30.7)ng/L화(179.6±30.5)ng/L,량조비교차이유통계학의의(P＜0.01).결론 좌선서체리진가능통과개선IL-13여IL-18이개선해수변이성효천환자적병정.
Objective To explore the effects of Levoeitirize dihydrochloride on interleukin-13(IL-13)and interleukin-18(IL-18)in the serum of the patients with cough variant asthma(CVA).Methods 70 cases with CVA were randomly devided into control group of 35 cases and treatment group of 35 cases.Control group was given Chlort rimeton and the treatment group was given Levocitirize dihydroehloride.The levels of IL-13 and IL-18 in the serum were measured before and after treatment.Results After treatment,the concentrations of IL-13 and IL-18 in patients in the treatment group were(46.7±17.3)ng/L and(145.2±27.1)ng/L，and those in the control group were(98.5±30.7)ng/L and(179.6±30.5)ne/L，which were significantly improved.Conclusion The treatmem of Levoeitirize dihydrochloride could improve the CVA through improving the production of IL-13 and IL-18.