CAJ | 학술논문

目的探讨抑郁障碍是否为老年冠心病的危险因素并观察冠心病伴抑郁障碍患者炎性标记物水平变化.方法对188例入选者进行临床情况调查、汉密顿抑郁量表评分和血清炎性标记物水平测定,分析冠心病伴抑郁障碍患病率及影响冠心病发病的危险因素.结果冠心病患者87例,其抑郁障碍患病率为29.9%(26例),非冠心病入选者101例,患病率为11.9%(12例),抑郁障碍在两组间差异有统计学意义(P＜0.01).年龄、高血压、糖尿病、脂代谢异常和抑郁障碍是冠心病的危险因素之一.冠心病伴抑郁障碍组和冠心病不伴抑郁障碍组入选者在突发生活事件、心功能分级差异有统计学意义(均P＜0.05).两组入选者在冠状动脉病变、冠状动脉病变治疗差异无统计学意义(P＞0.05).冠心病伴抑郁障碍组和冠心病不伴抑郁组外周血炎性标记物水平比较显示,伴抑郁障碍组血清单核细胞趋化因子-1水平增高,高敏C反应蛋白和肿瘤坏死因子α差异无统计学意义.结论老年冠心病患者伴抑郁障碍患病率高于老年非冠心患者群.抑郁障碍是影响冠心病发病的危险因素之一.老年冠心病患者抑郁障碍与炎性标记物之间可能存在一定关系.
목적 탐토억욱장애시부위노년관심병적위험인소병관찰관심병반억욱장애환자염성표기물수평변화.방법 대188례입선자진행림상정황조사、한밀돈억욱량표평분화혈청염성표기물수평측정,분석관심병반억욱장애환병솔급영향관심병발병적위험인소.결과 관심병환자87례,기억욱장애환병솔위29.9%(26례),비관심병입선자101례,환병솔위11.9%(12례),억욱장애재량조간차이유통계학의의(P＜0.01).년령、고혈압、당뇨병、지대사이상화억욱장애시관심병적위험인소지일.관심병반억욱장애조화관심병불반억욱장애조입선자재돌발생활사건、심공능분급차이유통계학의의(균P＜0.05).량조입선자재관상동맥병변、관상동맥병변치료차이무통계학의의(P＞0.05).관심병반억욱장애조화관심병불반억욱조외주혈염성표기물수평비교현시,반억욱장애조혈청단핵세포추화인자-1수평증고,고민C반응단백화종류배사인자α차이무통계학의의.결론 노년관심병환자반억욱장애환병솔고우노년비관심환자군.억욱장애시영향관심병발병적위험인소지일.노년관심병환자억욱장애여염성표기물지간가능존재일정관계.
Objective To explore whether depressive disorder is one of risk factors for coronary artery disease (CAD) in enrolled patients and observe the level of inflammation markers in coronary artery disease patients with depression. Methods In all patients, we recoded clinical information and data from Hamilton Depression Rating Scale for Depression( HRSD)and measured concentration of monocyte chemoattractant protein-1 (MCP-1), tumour necrosis factor α (TNFα) and hypersensitive C-reaction protein (hsCRP). Results Among 87 patients with coronary artery disease, depressive disorder was diagnosed in 26 patients, the prevalence of depressive disorder was 29. 9%. Among 101 patients without coronary artery disease, 12 patients were suffering from depressive disorder, the prevalence of depressive disorder was 11.90%. The prevalence of depressive disorder in coronary artery disease group was statistically higher than that in non-coronary heart disease group (29.8% vs.11.9%, P<0. 01). The incidence of coronary artery disease was associated with age, hypertension,diabetes mellitus, hypercholesterolemia and depression. Life events and stage of heart function occurred differently between CAD patients with and without depression (P<0. 05). There were no differences in the degree of coronary artery stenosis and the type of treatment (P>0. 05) between the two groups. There were higher concentration of MCP-1 in coronary artery disease patients with depression, but no remarkable difference in hsCRP and TNFa. Conclusions There is high prevalence of depressive disorder, which is one of risk factor for coronary artery disease. The depressive disorder may be associated with inflammation biomarker in patients with coronary artery disease.