CAJ | 학술논문

背景:盐酸多奈哌齐治疗阿尔茨海默病(Alzheimer disease,AD)受到临床关注,但其对认知功能及日常生活能力的改善是否有显著作用?目的:探讨盐酸多奈哌齐改善AD患者认知功能及日常生活能力的疗效,评价盐酸多奈哌齐治疗AD患者的有效性及安全性.设计:以诊断为依据的自身对照研究.地点和对象:1998-01/2001-03华中科技大学同济医学院附属梨园医院门诊和住院32例AD患者.干预:采用盐酸多奈哌齐5 mg/d治疗16周.治疗前后用简易智能精神状态检查量表(MMSE)、阿尔茨海默病评定量表(the Alzheimer diseaseassessment scale,ADAS)及Blessed-Roth Scale痴呆量表评定患者认知功能及痴呆严重程度、精神行为异常和日常生活自理能力,并进行安全性评价.主要观察指标:①AD患者治疗前后MMSE,ADAS,Blessed-Roth Scale痴呆量表评分.②AD患者治疗期间不良反应.结果:盐酸多奈哌齐治疗后,患者MMSE评分较治疗前平均提高(4.1±1.1)分(P＜0.01),ADAS认知部分改善(5.1±1.3)分(P＜0.05);Blessed-Roth日常生活自理能力改善(1.2±0.5)分(P＜0.05):ADAS的非认知行为部分减少(3.7±0.9)分,(P＜0.05),2例(6%)出现轻度副作用.结论:盐酸多奈哌齐治疗AD有较好的疗效并安全性好,副作用小.
배경:염산다내고제치료아이자해묵병(Alzheimer disease,AD)수도림상관주,단기대인지공능급일상생활능력적개선시부유현저작용?목적:탐토염산다내고제개선AD환자인지공능급일상생활능력적료효,평개염산다내고제치료AD환자적유효성급안전성.설계:이진단위의거적자신대조연구.지점화대상:1998-01/2001-03화중과기대학동제의학원부속리완의원문진화주원32례AD환자.간예:채용염산다내고제5 mg/d치료16주.치료전후용간역지능정신상태검사량표(MMSE)、아이자해묵병평정량표(the Alzheimer diseaseassessment scale,ADAS)급Blessed-Roth Scale치태량표평정환자인지공능급치태엄중정도、정신행위이상화일상생활자리능력,병진행안전성평개.주요관찰지표:①AD환자치료전후MMSE,ADAS,Blessed-Roth Scale치태량표평분.②AD환자치료기간불량반응.결과:염산다내고제치료후,환자MMSE평분교치료전평균제고(4.1±1.1)분(P＜0.01),ADAS인지부분개선(5.1±1.3)분(P＜0.05);Blessed-Roth일상생활자리능력개선(1.2±0.5)분(P＜0.05):ADAS적비인지행위부분감소(3.7±0.9)분,(P＜0.05),2례(6%)출현경도부작용.결론:염산다내고제치료AD유교호적료효병안전성호,부작용소.
BACKGROUND: Hydrochloric donepezil is paid much attention in clinic on its therapeutic use of Alzheimer Disease(AD), but does it also play a significant role in improving cognition and daily life ability of AD patients?OBJECTIVE: To discuss the curative effect of hydrochloric donepezil in improving cognition and daily life ability of AD patients and also to assess its validity and security in AD therapy.DESIGN: Self-controlled study based on diagnosis.SETTING and PARTICIPANTS: Thirty-two AD in and out patients of Affiliated Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 1998 to March 2001 were involved into our study.INTERVENTION: Hydrochloric donepezil(5 mg per day) was used for 16 weeks. Before and after treatment, mini-mental state examination (MMSE),the Alzheimer disease assessment scale(ADAS) and Blessed-Roth Scale were used to assess cognition ability, degree of dementia, abnormity of psychological behavior and dally life ability of the patients. Security of hydrochloric donepezil was also valued.RESULTS: After treatment the score of MMSE was increased 4. 1 ± 1.1 averagely( P ＜ 0.01 ), that of cognition part of ADAS was improved 5.1 ± 1.3 ( P ＜ 0. 05), that of Blessed-Both daily life ability was improved 1.2 ± 0. 5( P ＜ 0. 05), and that of Non-cognition part of ADAS was decreased 3.7 ±0.9( P ＜ 0. 05), and slight side effects occurred in 2 patients(6% ).CONCLUSION: Hydrochloric donepezil has good therapeutic effect and security and without obvious side effect in AD therapy.