CAJ | 학술논문

目的同顾性研究恶性血液病合并肺部真菌感染的危险因素.方法选择自1997年1月～2007年1月在我院诊断恶性血液病合并肺部真菌感染、细菌感染患者,对比分析其相关的危险因素,并进行统计学分析.结果共收集到符合条件的病例304例,其中真菌感染194例,占63.8%,细菌感染110例,占36.2%.单因素分析和Logistic多因素回归分析显示激素、晕轮征、既往真菌感染、ANC小于0.5×10~9L持续10 d以上、靠近胸膜的结节影、移植(免疫抑制剂使用)、化疗、广谱抗生素是恶性血液病合并肺部真菌感染的独立危险因素.结论恶性血液病合并肺部真菌感染具有多种危险因素,及早发现并及时进行抗真菌干预性治疗是非常必要的.
목적 동고성연구악성혈액병합병폐부진균감염적위험인소.방법 선택자1997년1월～2007년1월재아원진단악성혈액병합병폐부진균감염、세균감염환자,대비분석기상관적위험인소,병진행통계학분석.결과 공수집도부합조건적병례304례,기중진균감염194례,점63.8%,세균감염110례,점36.2%.단인소분석화Logistic다인소회귀분석현시격소、훈륜정、기왕진균감염、ANC소우0.5×10~9L지속10 d이상、고근흉막적결절영、이식(면역억제제사용)、화료、엄보항생소시악성혈액병합병폐부진균감염적독립위험인소.결론 악성혈액병합병폐부진균감염구유다충위험인소,급조발현병급시진행항진균간예성치료시비상필요적.
Objective To investigate the risk factors of pulmonary fungal infections related to hematologic malignancies.Methods A retrospective case-controlled study was conducted to analyze the patients with pulmonary fungal and bacterial infections in association with hematologic malignancies.The risk factors of pulmonary fungal infections related to hematologic malignancies were identified.Results Three hundred and four cases(194 of pulmonary fungal infections and 110 of pulmonary bacterial infections)were enrolled in this study.Univariate analysis and multivariate logistic regression show that such factors as corticosteroid, halo sign,previous fungal infections,ANC lower than 0.5×10~9/L for over 10 days, nodns near pleura,transplantation.(immunodepressant use), chemotherapy, and broad spectrum antibiotics were all the independent risk factors of pulmonary fungal infections related to hematologic malignancies.Conclusion There are many risk factors for pulmonary fungal infections related to hematologic malignancies, and early identification of these factors for timely antifungal treatment is of much clinical significance.