国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
6期
762-766
,共5页
白细胞介素-12%急性放射病%外周血象
白細胞介素-12%急性放射病%外週血象
백세포개소-12%급성방사병%외주혈상
Interleukin-12(IL-12)%Acute radiation sickness%Peripheral blood
目的 观察白细胞介素-12(IL-12)对致死剂量γ射线照射致急性放射病小鼠的救治作用.方法 将实验小鼠经γ射线照射造模成功后分为生理盐水组,IL-12低、中、高剂量组和尼尔雌醇阳性对照组.记录小鼠存活天数,统计生存率；比较辐射前后血液中粒细胞、红细胞和血小板值.结果 给予rmIL-12治疗的小鼠存活时间长,存活率高.IL-12可明显升高受辐射小鼠外周血红细胞数、粒细胞数和血小板数.结论 IL-12对辐射后小鼠具有一定的救治作用.
目的 觀察白細胞介素-12(IL-12)對緻死劑量γ射線照射緻急性放射病小鼠的救治作用.方法 將實驗小鼠經γ射線照射造模成功後分為生理鹽水組,IL-12低、中、高劑量組和尼爾雌醇暘性對照組.記錄小鼠存活天數,統計生存率；比較輻射前後血液中粒細胞、紅細胞和血小闆值.結果 給予rmIL-12治療的小鼠存活時間長,存活率高.IL-12可明顯升高受輻射小鼠外週血紅細胞數、粒細胞數和血小闆數.結論 IL-12對輻射後小鼠具有一定的救治作用.
목적 관찰백세포개소-12(IL-12)대치사제량γ사선조사치급성방사병소서적구치작용.방법 장실험소서경γ사선조사조모성공후분위생리염수조,IL-12저、중、고제량조화니이자순양성대조조.기록소서존활천수,통계생존솔；비교복사전후혈액중립세포、홍세포화혈소판치.결과 급여rmIL-12치료적소서존활시간장,존활솔고.IL-12가명현승고수복사소서외주혈홍세포수、립세포수화혈소판수.결론 IL-12대복사후소서구유일정적구치작용.
Objective To observe the effects of interleukin-12(IL-12) in the mice with lethal dose of γ -ray irradiation.Methods The mice were radiated and divided into five groups:irradiation alone,IL-12 with low,medium and high-dose,nilestriol positive control.The survival days of mice were recorded,the value of red blood cell (RBC),granule cell and blood platelet were compared before and after radiation exposure.Results IL-12 can significantly increase the survival days of mice, and raise the survival rate after lethal dose radiation and the level of RBC,granule cell and blood platelet.Conclusion IL-12 has certain effects of remedy to mice exposed to lethal radiation.
