国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
8期
628-633
,共6页
基质金属蛋白酶-9%非小细胞肺癌%侵袭和转移
基質金屬蛋白酶-9%非小細胞肺癌%侵襲和轉移
기질금속단백매-9%비소세포폐암%침습화전이
Matrix metalloproteinases-9%Non-small cell lung cancer%Invasion and metastasis
非小细胞肺癌( NSCLC)占肺癌80％以上,常常在病变后期才被诊断出,大部分已发生浸润、转移,预后极差.细胞外基质(ECM)降解是引起肺癌侵袭、转移发生的主要因素.基质金属蛋白酶(matrix metalloproteinases,MMP)是一大族对ECM成分有特异降解作用的蛋白酶,通过降解ECM在NSCLC浸润和转移中起重要作用.MMP-9在体内、外多种恶性肿瘤中呈过表达,且可特异性降解基底膜,已成为MMP家族在恶性肿瘤进展方面的研究热点.
非小細胞肺癌( NSCLC)佔肺癌80％以上,常常在病變後期纔被診斷齣,大部分已髮生浸潤、轉移,預後極差.細胞外基質(ECM)降解是引起肺癌侵襲、轉移髮生的主要因素.基質金屬蛋白酶(matrix metalloproteinases,MMP)是一大族對ECM成分有特異降解作用的蛋白酶,通過降解ECM在NSCLC浸潤和轉移中起重要作用.MMP-9在體內、外多種噁性腫瘤中呈過錶達,且可特異性降解基底膜,已成為MMP傢族在噁性腫瘤進展方麵的研究熱點.
비소세포폐암( NSCLC)점폐암80％이상,상상재병변후기재피진단출,대부분이발생침윤、전이,예후겁차.세포외기질(ECM)강해시인기폐암침습、전이발생적주요인소.기질금속단백매(matrix metalloproteinases,MMP)시일대족대ECM성분유특이강해작용적단백매,통과강해ECM재NSCLC침윤화전이중기중요작용.MMP-9재체내、외다충악성종류중정과표체,차가특이성강해기저막,이성위MMP가족재악성종류진전방면적연구열점.
Non-small cell lung cancer (NSCLC) which represents 80％ of lung cancer,is ofen diagnosed with advanced disease, characterized by invasion and metastasis. The degradation of extracellular matrix (ECM) is one of the important factors related to lung neoplasms invasion and metastasis.Matrix metalloproteinases (MMP),which is a member of the large family of proteases with the ability to degrade ECM,plays pivotal roles in NSCLC invasion and metastasis.A growing body of literatures suggests that MMP-9 is unregulated in malignant tumors both in vitro and in vivo,thus leading to a specific degradation of ECM.
