中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
7期
29-32
,共4页
脑血管意外%C反应蛋白质
腦血管意外%C反應蛋白質
뇌혈관의외%C반응단백질
Cerebrovascular accident%C-reactive protein
目的 探讨不同亚型急性缺血性卒中(AIS)患者血清高敏C反应蛋白(hs-CRP)水平的变化及其意义.方法 124例AIS患者按照低分子肝素试验(TOAST)标准进行病因学分型:大动脉粥样硬化(LAA)型47例,小动脉闭塞(SVO)型37例,心源性栓塞(CE)型21例,其他明确原因(ODE)型和原因不明(UE)型19例.患者于入院第2天(发病后72 h内)、第7天和第14天分别抽血检测hs-CRP水平,并与81例健康体检者(对照组)进行比较.结果 LAA型患者发病后72 h内、发病后1周、发病后2周时血清hs-CRP水平分别为(10.77±4.27)、(16.41±5.61)、(7.63±3.59)mg/L;SVO型分别为(3.99±1.56)、(6.45±3.25)、(4.22±3.21)mg/L;CE型分别为(11.60±4.85)、(25.14±7.12)、(9.24±4.61)nag]L;ODE及UE型分别为(6.09±2.43)、(9.65±4.65)、(5.89±2.68)mg/L.除SVO型血清hs-CRP水平与对照组(4.26±1.34)mg/L比较差异无统计学意义外,其余各型不均明显高于对照组;而且除SVO型不同时间血清hs-CRP水平比较差异无统计学意义(P>0.05)外,其他各型同时间血清hs-CRP水平比较差异均有统计学意义(P<0.05).结论 AIS患者血清hs-CRP水平增高,与疾病严重程度呈正相关,从TOAST各亚型变化不同表现出来,并随发病后的时间而变化.提示炎性反应可能在AIS的病理机制中起重要作用.
目的 探討不同亞型急性缺血性卒中(AIS)患者血清高敏C反應蛋白(hs-CRP)水平的變化及其意義.方法 124例AIS患者按照低分子肝素試驗(TOAST)標準進行病因學分型:大動脈粥樣硬化(LAA)型47例,小動脈閉塞(SVO)型37例,心源性栓塞(CE)型21例,其他明確原因(ODE)型和原因不明(UE)型19例.患者于入院第2天(髮病後72 h內)、第7天和第14天分彆抽血檢測hs-CRP水平,併與81例健康體檢者(對照組)進行比較.結果 LAA型患者髮病後72 h內、髮病後1週、髮病後2週時血清hs-CRP水平分彆為(10.77±4.27)、(16.41±5.61)、(7.63±3.59)mg/L;SVO型分彆為(3.99±1.56)、(6.45±3.25)、(4.22±3.21)mg/L;CE型分彆為(11.60±4.85)、(25.14±7.12)、(9.24±4.61)nag]L;ODE及UE型分彆為(6.09±2.43)、(9.65±4.65)、(5.89±2.68)mg/L.除SVO型血清hs-CRP水平與對照組(4.26±1.34)mg/L比較差異無統計學意義外,其餘各型不均明顯高于對照組;而且除SVO型不同時間血清hs-CRP水平比較差異無統計學意義(P>0.05)外,其他各型同時間血清hs-CRP水平比較差異均有統計學意義(P<0.05).結論 AIS患者血清hs-CRP水平增高,與疾病嚴重程度呈正相關,從TOAST各亞型變化不同錶現齣來,併隨髮病後的時間而變化.提示炎性反應可能在AIS的病理機製中起重要作用.
목적 탐토불동아형급성결혈성졸중(AIS)환자혈청고민C반응단백(hs-CRP)수평적변화급기의의.방법 124례AIS환자안조저분자간소시험(TOAST)표준진행병인학분형:대동맥죽양경화(LAA)형47례,소동맥폐새(SVO)형37례,심원성전새(CE)형21례,기타명학원인(ODE)형화원인불명(UE)형19례.환자우입원제2천(발병후72 h내)、제7천화제14천분별추혈검측hs-CRP수평,병여81례건강체검자(대조조)진행비교.결과 LAA형환자발병후72 h내、발병후1주、발병후2주시혈청hs-CRP수평분별위(10.77±4.27)、(16.41±5.61)、(7.63±3.59)mg/L;SVO형분별위(3.99±1.56)、(6.45±3.25)、(4.22±3.21)mg/L;CE형분별위(11.60±4.85)、(25.14±7.12)、(9.24±4.61)nag]L;ODE급UE형분별위(6.09±2.43)、(9.65±4.65)、(5.89±2.68)mg/L.제SVO형혈청hs-CRP수평여대조조(4.26±1.34)mg/L비교차이무통계학의의외,기여각형불균명현고우대조조;이차제SVO형불동시간혈청hs-CRP수평비교차이무통계학의의(P>0.05)외,기타각형동시간혈청hs-CRP수평비교차이균유통계학의의(P<0.05).결론 AIS환자혈청hs-CRP수평증고,여질병엄중정도정정상관,종TOAST각아형변화불동표현출래,병수발병후적시간이변화.제시염성반응가능재AIS적병리궤제중기중요작용.
Objective To explore, the levels of serum highsensitive C-reactive protein (hs-CRP) in different subtypes of acute ischemic stroke (AIS) and its significance. Methods According to TOAST criteria, 124 cases of AIS were divided into four groups: large-artery atherosclerosis (LAA,47 cases), small-artery occlusion (SVO,37 cases), cardiogenic cerebral embolism (CE,21 cases), acute stroke of other determined etiology and stroke of other undetermined etiology (ODE and UE, 19 cases). The serum concentration of hs-CRP was measured with the immunoturbidimetry in every patient of each group at 72 hours, 7 and 14 days after admitted to hospital. Meanwhile 81 healthy persons were involved in control group. Results The serum concentrations of hs-CRP at 72 hours, 7 and 14 days after onset were (10.77 ± 4.27),(16.41±5.61), (7.63±3.59) mg/L in LAA group;(3.99± 1.56), (6.45±3.25), (4.22±3.21) mg/L in SVO group; (11.60±4.85), (25.14±7.12), (9.24±4.61) mg/L in CE group; (6.09±2.43), (9.65 ±4.65), (5.89 ± 2.68) mg/L in ODE and UE group. The serum concentrations of hs-CRP in LAA group, CE group, ODE and UE group were significantly higher than those in control group [(4.26 ± 1.34) mg/L] (P <0.05) except for that in SVO group, the level of serum hs-CRP in the three groups showed significant difference among the different time (P< 0.05). Conclusions The level of serum hs-CRP in AIS patients is increased and positively correlated with the disease severity. The changes of hs-CRP level are performed in various subtypes of TOAST, and show time-dependent effects. Inflammatory response may play an important role in the pathological mechanism of AIS.
