CAJ | 학술논문

目的探讨妊娠期高血压疾病患者血清脂源性细胞因子(Apelin、抵抗素)水平的变化及其意义.方法以98例妊娠期高血压疾病孕妇为研究组(其中轻度子痫前期36例、重度子痫前期32例),30例同期分娩的正常孕妇为对照组,采用ELISA法检测血清Apelin和抵抗素水平;同时检测血脂水平.结果轻度、重度子痫前期患者血清Apelin和抵抗素水平明显高于对照组,差异有统计学意义(P<0.05).妊娠期高血压疾病患者血清Apelin和抵抗素与TG、TC、LDL-C、HDL-C之间均呈显著相关(P<0.01).妊娠期高血压疾病患者血清Apelin及抵抗素水平呈高度正相关(r=0.670,P<0.01).结论Apelin、抵抗素等脂源性细胞因子在妊娠期高血压疾病的发病中可能发挥一定的作用.
목적 탐토임신기고혈압질병환자혈청지원성세포인자(Apelin、저항소)수평적변화급기의의.방법 이98례임신기고혈압질병잉부위연구조(기중경도자간전기36례、중도자간전기32례),30례동기분면적정상잉부위대조조,채용ELISA법검측혈청Apelin화저항소수평;동시검측혈지수평.결과 경도、중도자간전기환자혈청Apelin화저항소수평명현고우대조조,차이유통계학의의(P<0.05).임신기고혈압질병환자혈청Apelin화저항소여TG、TC、LDL-C、HDL-C지간균정현저상관(P<0.01).임신기고혈압질병환자혈청Apelin급저항소수평정고도정상관(r=0.670,P<0.01).결론Apelin、저항소등지원성세포인자재임신기고혈압질병적발병중가능발휘일정적작용.
Objective To clarify the role of adipocytokine,apelin and resistin in the pathogenesis of hyper-tension disorder complicating pregnancy(HDCP). Methods The serum levels of apelin and resistin were measured using the enzyme-linked immunosorbent assay in 68 HDCP patients and 30 normotensive pregnant women. 98 women were divided into three groups: group A consisted of 30 normotensive pregnant women (NPW) ;group B consisted of 36 women with mild pre-eelampsia(MPE) ;and group C consisted of 32 women with severe pre-eclampsia(SPE). Results The serum levels of apelin and resistin in women with MPE or SPE were respectively significantly higher than those in NPW(P<0.01 ). Serum levels of apelin and resistin were correlated significantly with TG ,TC, and LDL-C, HDL-C in HDCP women (P<0.01). There was a correlation between the serum levels of apelin and resistin in HDCP women (r=0.670, P<0.01). Conclusion These findings suggest that apelin and resistin may be involved in the pathogenesis of HDCP. Moreover,reduced serum concentrations of apelin and elevated resistin are associated with development of severe disease.