中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2011年
9期
940-945
,共6页
丙型肝炎%危险因素%Meta分析
丙型肝炎%危險因素%Meta分析
병형간염%위험인소%Meta분석
Hepatitis C%Risk factor%Meta analysis
目的 分析丙型肝炎病毒(HCV)感染的危险因素。方法计算机检索中国医院知识仓库(CHKD)、万方数据知识平台、EBSCO、西文生物医学期刊文献服务系统、Elsevier，并结合文献追溯的方法，收集1994-2010年公开发表的关于HCV感染危险因素的文献，研究类型为病例对照研究或队列研究，采用RevMan 5.0及Stata 11.0软件对所选取的危险因素进行异质性检验、合并比值比(OR)及95％可信区间(CI)。结果共纳入25篇病例对照研究的文献，累计病例4370人、对照8606人。单因素分析合并的OR值及95％CI依次为：输血史4.23(2.82～6.35)、手术史2.13（1.70 ～ 2.67）、静脉注射吸毒史52.28(34.12～80.11)、性伴为静脉吸毒者7.19(3.13～16.51)、性病史3.43 (2.70 ～4.34)。多因素分析合并的OR值及95％CI为：输血史6.03(3.97 ～ 9.15)、手术史2.10(1.44～ 3.07)、静脉注射吸毒史44.90(31.13～64.76)、性伴为静脉吸毒者3.87(2.07～7.24)、性病史2.05(1.19 ～3.52)。结论HCV的危险因素为输血史、静脉注射吸毒史和性伴为静脉吸毒者；由于存在偏倚，还不能确定手术史是否为HCV感染的独立危险因素；性病史与HCV的感染呈弱相关，但结果不稳定，需要进一步研究。
目的 分析丙型肝炎病毒(HCV)感染的危險因素。方法計算機檢索中國醫院知識倉庫(CHKD)、萬方數據知識平檯、EBSCO、西文生物醫學期刊文獻服務繫統、Elsevier，併結閤文獻追溯的方法，收集1994-2010年公開髮錶的關于HCV感染危險因素的文獻，研究類型為病例對照研究或隊列研究，採用RevMan 5.0及Stata 11.0軟件對所選取的危險因素進行異質性檢驗、閤併比值比(OR)及95％可信區間(CI)。結果共納入25篇病例對照研究的文獻，纍計病例4370人、對照8606人。單因素分析閤併的OR值及95％CI依次為：輸血史4.23(2.82～6.35)、手術史2.13（1.70 ～ 2.67）、靜脈註射吸毒史52.28(34.12～80.11)、性伴為靜脈吸毒者7.19(3.13～16.51)、性病史3.43 (2.70 ～4.34)。多因素分析閤併的OR值及95％CI為：輸血史6.03(3.97 ～ 9.15)、手術史2.10(1.44～ 3.07)、靜脈註射吸毒史44.90(31.13～64.76)、性伴為靜脈吸毒者3.87(2.07～7.24)、性病史2.05(1.19 ～3.52)。結論HCV的危險因素為輸血史、靜脈註射吸毒史和性伴為靜脈吸毒者；由于存在偏倚，還不能確定手術史是否為HCV感染的獨立危險因素；性病史與HCV的感染呈弱相關，但結果不穩定，需要進一步研究。
목적 분석병형간염병독(HCV)감염적위험인소。방법계산궤검색중국의원지식창고(CHKD)、만방수거지식평태、EBSCO、서문생물의학기간문헌복무계통、Elsevier，병결합문헌추소적방법，수집1994-2010년공개발표적관우HCV감염위험인소적문헌，연구류형위병례대조연구혹대렬연구，채용RevMan 5.0급Stata 11.0연건대소선취적위험인소진행이질성검험、합병비치비(OR)급95％가신구간(CI)。결과공납입25편병례대조연구적문헌，루계병례4370인、대조8606인。단인소분석합병적OR치급95％CI의차위：수혈사4.23(2.82～6.35)、수술사2.13（1.70 ～ 2.67）、정맥주사흡독사52.28(34.12～80.11)、성반위정맥흡독자7.19(3.13～16.51)、성병사3.43 (2.70 ～4.34)。다인소분석합병적OR치급95％CI위：수혈사6.03(3.97 ～ 9.15)、수술사2.10(1.44～ 3.07)、정맥주사흡독사44.90(31.13～64.76)、성반위정맥흡독자3.87(2.07～7.24)、성병사2.05(1.19 ～3.52)。결론HCV적위험인소위수혈사、정맥주사흡독사화성반위정맥흡독자；유우존재편의，환불능학정수술사시부위HCV감염적독립위험인소；성병사여HCV적감염정약상관，단결과불은정，수요진일보연구。
Objective To provide evidence for decision-making on primary hepatitis C prevention through analyzing the main risk factors of hepatitis C virus infection. Methods A comprehensive search was carried out in China Hospital Knowledge Database (CHKD), Wanfang Data, EBSCO, FMJS and Elsevier databases to identify all case-control and cohort studies published from 1994 to 2010 that evaluated the risk factors on the transmission of hepatitis C virus. Data manipulation and statistical analyses were performed using Stata 11.0 and RevMan 5.0 softwares.Results A total of 25 case-control studies were included in this Meta-analysis, which contained 4370 cases and 8606 controls. In univariate analysis, the pooled odds ratio (OR) and 95％ confidence interval (CI) on the risk factors associated with HCV seropositivity were "blood transfusion" 4.23 (2.82-6.35) , "having had surgical operations" 2.13 (1.70-2.67) , "intravenous drug use" 52.28(34.12-80.11 ), "having sex with intravenous drug users" 7.19 ( 3.13- 16.51 ), "histories of having had STDs" 3.43 (2.70-4.34). In multivariate analysis, pooled OR and 95％CI of the risk factors associated with HCV seropositivity were: having had following "histories as blood transfusion" 6.03 (3.97-9.15), "surgeries" 2.10( 1.44-3.07), "intravenous drug use" 44.90(31.13-64.76), "having sex with intravenous drug users" 3.87(2.07-7.24), "having STDs" 2.05(1.19-3.52). Conclusion Blood transfusion、 intravenous drug use and having sex with intravenous drug users were the risk factors of HCV infection. Due to existing biases, the relationship between having had surgical operations and HCV infection was inconclusive. There appeared weak correlation between STDs and HCV infection,but the result was not so stability.
