无机化学学报
無機化學學報
무궤화학학보
JOURNAL OF INORGANIC CHEMISTRY
2005年
4期
468-471
,共4页
徐宏%张鹏%杜芬%周兵瑞%梁毅%刘剑洪%刘志刚%计亮年
徐宏%張鵬%杜芬%週兵瑞%樑毅%劉劍洪%劉誌剛%計亮年
서굉%장붕%두분%주병서%량의%류검홍%류지강%계량년
钌(Ⅱ)多吡啶配合物%CT DNA%ITC%相互作用
釕(Ⅱ)多吡啶配閤物%CT DNA%ITC%相互作用
조(Ⅱ)다필정배합물%CT DNA%ITC%상호작용
Ruthenium(Ⅱ) polypyridyl complexes%CT DNA%ITC%Interaction
The interaction of ruthenium(Ⅱ) polypyridyl complex with DNA has been studied by isothermal titrationcalorimetry (ITC). The results show that complex [Ru(phen)2PMIP]2+ {phen=1,10-phenanthroline, PMIP=2-(4-methylphenyl)imidazo[4,5-f]l,10-phenanthroline} interacts with calf thymus DNA (CT DNA) in terms of a modelfor a single set of identical sites through intercalation. The results are in agreement with our previous observationsfrom spectroscopic methods and viscosity measurements. In addition, the results further show that the drivingforce for DNA binding with the complex is mainly driven by the enthalpy changes, and the contribution from theentropy changes to this driving force is negligible.
