中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2009年
4期
602-607
,共6页
胡继华%刘彦慧%郑德清%曾丽萍%顾红祥%关晓东
鬍繼華%劉彥慧%鄭德清%曾麗萍%顧紅祥%關曉東
호계화%류언혜%정덕청%증려평%고홍상%관효동
染色体%诊断%浆膜腔积液,恶性
染色體%診斷%漿膜腔積液,噁性
염색체%진단%장막강적액,악성
Chromosomes%Diagnosis%Serous effusion,malignant
目的 探讨细胞染色体检测对诊断恶性多浆膜腔积液的价值.方法 染色体检测采取涂片染色镜检定性的方法 .本研究共有43例恶性肿瘤和30例非恶性肿瘤伴多浆膜腔积液的患者,对其浆膜腔积液均进行了染色体、癌细胞、CEA等检查.结果 浆膜腔积液染色体检测的敏感性为79.07%,准确性为92.65%,明显优于癌细胞、CEA的检测结果 (P＜0.05,P＜0.01),且特异性高达96.67%.31例恶性肿瘤伴渗出性多浆膜腔积液患者中,28例染色体阳性,阳性检出率为90.32%;12例恶性肿瘤伴非渗出性多浆膜腔积液患者中,6例染色体阳性,阳性检出率为50.00%,两组阳性率均较高,但经比较P＜0.05.结论 恶性肿瘤患者伴发多浆膜腔积液时,无论是渗出液还是非渗出液,其染色体阳性检出率和特异性都很高,对诊断恶性多浆膜腔积液具有很好的临床实用价值,但非渗出液的细胞培养时间应适当延长.
目的 探討細胞染色體檢測對診斷噁性多漿膜腔積液的價值.方法 染色體檢測採取塗片染色鏡檢定性的方法 .本研究共有43例噁性腫瘤和30例非噁性腫瘤伴多漿膜腔積液的患者,對其漿膜腔積液均進行瞭染色體、癌細胞、CEA等檢查.結果 漿膜腔積液染色體檢測的敏感性為79.07%,準確性為92.65%,明顯優于癌細胞、CEA的檢測結果 (P＜0.05,P＜0.01),且特異性高達96.67%.31例噁性腫瘤伴滲齣性多漿膜腔積液患者中,28例染色體暘性,暘性檢齣率為90.32%;12例噁性腫瘤伴非滲齣性多漿膜腔積液患者中,6例染色體暘性,暘性檢齣率為50.00%,兩組暘性率均較高,但經比較P＜0.05.結論 噁性腫瘤患者伴髮多漿膜腔積液時,無論是滲齣液還是非滲齣液,其染色體暘性檢齣率和特異性都很高,對診斷噁性多漿膜腔積液具有很好的臨床實用價值,但非滲齣液的細胞培養時間應適噹延長.
목적 탐토세포염색체검측대진단악성다장막강적액적개치.방법 염색체검측채취도편염색경검정성적방법 .본연구공유43례악성종류화30례비악성종류반다장막강적액적환자,대기장막강적액균진행료염색체、암세포、CEA등검사.결과 장막강적액염색체검측적민감성위79.07%,준학성위92.65%,명현우우암세포、CEA적검측결과 (P＜0.05,P＜0.01),차특이성고체96.67%.31례악성종류반삼출성다장막강적액환자중,28례염색체양성,양성검출솔위90.32%;12례악성종류반비삼출성다장막강적액환자중,6례염색체양성,양성검출솔위50.00%,량조양성솔균교고,단경비교P＜0.05.결론 악성종류환자반발다장막강적액시,무론시삼출액환시비삼출액,기염색체양성검출솔화특이성도흔고,대진단악성다장막강적액구유흔호적림상실용개치,단비삼출액적세포배양시간응괄당연장.
Objective To study the diagnostic value of malignant polyserositis with chromosome.Methods The chromosome were measured with microscope after smear and stain.The chromosome,cancer cell,CEA were detected in all the 43 tumor patients and all the 30 non-tumor patients with polyserositis.Results The sensitivity of the chromosome detection was 79.07%,the accuracy was 92.65%,they showed statistically significant superior versus the cancer cell,CEA detection(P<0.05,P<0.01);and the specificity was 96.67%.In the percolate of 31 tumor patients,28 results of patient′s chromosome detection were positive,the positive rate was 90.32%;In the non-percolate of 12 tumor patients,6 results of patient′s chromosome detection were positive,the positive rate was 50.00%;Both of them had higher positive,but they showed statistically significant differences too,P<0.05.Conclusions The results of chromosome detection had better sensitivity and specificity,not only in the percolate of tumor patients but also in the non-percolate of tumor patients.It is more useful in diagnosis of the malignant polyserositis,but it should be longer periods with the breeding cell in the non-percolate of tumor patients.
