CAJ | 학술논문

本试验通过灌胃小鼠纯化蓖麻毒素(1/5 LD50),对毒素在机体内对胃肠道及免疫器官的毒效应进行了分析.中毒初期,小鼠体增重及胸腺、脾脏相对重均明显下降,随着毒素的不断排出,小鼠的体征有恢复正常的迹象.病理切片、扫描电镜及透射电镜的结果表明,蓖麻毒素可引起一系列肠道病理反应,肠粘膜损伤极其严重;脾细胞发生明显的凋亡和坏死症状.
본시험통과관위소서순화비마독소(1/5 LD50),대독소재궤체내대위장도급면역기관적독효응진행료분석.중독초기,소서체증중급흉선、비장상대중균명현하강,수착독소적불단배출,소서적체정유회복정상적적상.병리절편、소묘전경급투사전경적결과표명,비마독소가인기일계렬장도병리반응,장점막손상겁기엄중;비세포발생명현적조망화배사증상.
The experiment aimed to study the toxic effect of oral ricin on gastrointestinal tract and immune organs of mice with the dose of 1/5 LD50.In early days of intoxication,there was an obviously decrease in daffy weight and relative weight of thymus and spleen,fllowing the excretion of toxin,they had a trend of recovering to the normal state.Also,results of pathological section,scanning electron microscope and transmission electron microscope showed that ricin would induce a series of pathological reaction in intestines,meanwhile,the splenocytes displayed significant symptom of apoptosis and necrosis.