国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2009年
4期
627-630
,共4页
视网膜硬性渗出%血脂分析%2型糖尿病
視網膜硬性滲齣%血脂分析%2型糖尿病
시망막경성삼출%혈지분석%2형당뇨병
retinal hard exudates%lipid profile%diabetes mellitus type 2
目的:研究血脂分析结果与糖尿病性视网膜病之间的关系,以及2型糖尿患者合并其他系统疾病之间氧化低密度脂蛋白的关系.方法:横断面研究,包括40位糖尿病并糖尿病性视网膜病患者和40位糖尿病不并有糖尿病性视网膜病患者.收集人口学资料,进行详细眼科检查.空腹采集9mL静脉血,分析血清胆固醇,甘油三酯,高密度脂蛋白,低密度脂蛋白,氧化低密度脂蛋白和糖化血红蛋白.结果:糖尿病性视网膜病组平均血清胆固醇为5.9±1.86mmol/L,非糖尿病性视网膜病组为5.0±1.03mmol/L(P=0.001).糖尿病性视网膜病组血清低密度脂蛋白为3.6±1.69mmol/L,而对照组为3.0±1.02mmol/L(P=0.005).与轻至中度视网膜硬性渗出患者比较,重度视网膜硬性渗出患者血清胆固醇,甘油三酯和低密度脂蛋白较高,但是差异无统计学意义(P=0.082, 0.116, 0.218).重度硬性渗出患者的平均血清氧化低密度脂蛋白较轻至中度者高.糖尿病病史长短以及是否合并其他系统疾病之间平均氧化低密度脂蛋白无统计学显著性差异.结论:血清胆固醇和低密度脂蛋白与糖尿病性视网膜病显著相关,而血清血脂分析结果与视网膜硬性渗出严重度不相关.我们研究发现,血清氧化低密度脂蛋白与糖尿病性视网膜病及合并的其他系统疾病之间无相关关系.
目的:研究血脂分析結果與糖尿病性視網膜病之間的關繫,以及2型糖尿患者閤併其他繫統疾病之間氧化低密度脂蛋白的關繫.方法:橫斷麵研究,包括40位糖尿病併糖尿病性視網膜病患者和40位糖尿病不併有糖尿病性視網膜病患者.收集人口學資料,進行詳細眼科檢查.空腹採集9mL靜脈血,分析血清膽固醇,甘油三酯,高密度脂蛋白,低密度脂蛋白,氧化低密度脂蛋白和糖化血紅蛋白.結果:糖尿病性視網膜病組平均血清膽固醇為5.9±1.86mmol/L,非糖尿病性視網膜病組為5.0±1.03mmol/L(P=0.001).糖尿病性視網膜病組血清低密度脂蛋白為3.6±1.69mmol/L,而對照組為3.0±1.02mmol/L(P=0.005).與輕至中度視網膜硬性滲齣患者比較,重度視網膜硬性滲齣患者血清膽固醇,甘油三酯和低密度脂蛋白較高,但是差異無統計學意義(P=0.082, 0.116, 0.218).重度硬性滲齣患者的平均血清氧化低密度脂蛋白較輕至中度者高.糖尿病病史長短以及是否閤併其他繫統疾病之間平均氧化低密度脂蛋白無統計學顯著性差異.結論:血清膽固醇和低密度脂蛋白與糖尿病性視網膜病顯著相關,而血清血脂分析結果與視網膜硬性滲齣嚴重度不相關.我們研究髮現,血清氧化低密度脂蛋白與糖尿病性視網膜病及閤併的其他繫統疾病之間無相關關繫.
목적:연구혈지분석결과여당뇨병성시망막병지간적관계,이급2형당뇨환자합병기타계통질병지간양화저밀도지단백적관계.방법:횡단면연구,포괄40위당뇨병병당뇨병성시망막병환자화40위당뇨병불병유당뇨병성시망막병환자.수집인구학자료,진행상세안과검사.공복채집9mL정맥혈,분석혈청담고순,감유삼지,고밀도지단백,저밀도지단백,양화저밀도지단백화당화혈홍단백.결과:당뇨병성시망막병조평균혈청담고순위5.9±1.86mmol/L,비당뇨병성시망막병조위5.0±1.03mmol/L(P=0.001).당뇨병성시망막병조혈청저밀도지단백위3.6±1.69mmol/L,이대조조위3.0±1.02mmol/L(P=0.005).여경지중도시망막경성삼출환자비교,중도시망막경성삼출환자혈청담고순,감유삼지화저밀도지단백교고,단시차이무통계학의의(P=0.082, 0.116, 0.218).중도경성삼출환자적평균혈청양화저밀도지단백교경지중도자고.당뇨병병사장단이급시부합병기타계통질병지간평균양화저밀도지단백무통계학현저성차이.결론:혈청담고순화저밀도지단백여당뇨병성시망막병현저상관,이혈청혈지분석결과여시망막경성삼출엄중도불상관.아문연구발현,혈청양화저밀도지단백여당뇨병성시망막병급합병적기타계통질병지간무상관관계.
AIM: To study the association between lipid profile and retinal hard exudates in diabetic retinopathy (DR) and the association between oxidized-LDL with systemic diseases among type 2 diabetic patients.another 40 patients without DR. Demographic data was collected and comprehensive ocular examination was performed. Nine mL venous blood was taken for fasting serum cholesterol, triglycerides, HDL, LDL, ox-LDL, and for HbA1C. Compared to patients without retinopathy 5.0±1.03mmol/L (P=0.001). The mean serum LDL was 3.6±1.69mmol/L in retinopathy group compared to 3.0±1.02mmol/L in the contol group (P=0.005). There was a higher concentration of serum cholesterol, triglyceride and LDL in patients with severe retinal hard exudates compared to those with mild and moderate, however it was not statistically significant (P=0.082, 0.116, 0.218) respectively. The mean serum oxidized-LDL concentration was higher in DR with severe retinal hard exudates compared to mild and moderate. There was no statistically significant difference in the mean oxidized LDL with other systemic diseases or duration of diabetes.and LDL with DR. However there was no association between serum lipid profile with the severity of retinal hard exudates. Serum ox-LDL was also not associated with DR and other systemic co-morbidities in our study.
