中华劳动卫生职业病杂志
中華勞動衛生職業病雜誌
중화노동위생직업병잡지
CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
2012年
1期
17-20
,共4页
郭瑶静%林大枫%易继湖%旷聃%邓华欣%李晓海%张志虎%邬堂春
郭瑤靜%林大楓%易繼湖%曠聃%鄧華訢%李曉海%張誌虎%鄔堂春
곽요정%림대풍%역계호%광담%산화흔%리효해%장지호%오당춘
甲醛%职业暴露%微核试验
甲醛%職業暴露%微覈試驗
갑철%직업폭로%미핵시험
Formaldehyde%Occupational exposure%Micronucleus tests
目的 探讨职业性甲醛接触对工人外周血淋巴细胞微核率(CBMN)的影响.方法 选择山东省某人造密度板厂2个有代表性的车间,使用高效液相色谱法测定空气甲醛浓度,采集236名工人的外周静脉血,酶联免疫分析法测定内暴露标志物血清甲醛-白蛋白加合物(FA-HSA)的含量,根据内暴露标志物的三分位数将人群分为低、中、高水平3个接触组,用胞质分裂阻滞法微核试验检测外周血淋巴细胞遗传物质的损伤情况.结果 低甲醛接触车间和高甲醛接触车间的平均空气甲醛含量分别为(0.58:±-0.20)、(1.48±0.61)mg/m3,接触工人血清中FA-HSA平均水平分别为(69.22±15.37)、(136.29±89.49)pg/ml,差异均有统计学意义(P<0.01).低、中、高接触组工人外周血淋巴细胞CBMN分别为1.94‰±1.72%、2.10‰±1.92‰、2.10‰±1.70‰,各组间CBMN的差异无统计学意义(P>0.05).低、中、高累积接触水平组CBMN分别为1.36‰±1.36%o、2.31o±:1.81‰、2.49‰±1.92‰,不同累积接触水平组工人外周血淋巴细胞CBMN的差异有统计学意义(P<0.01).Spearman相关分析发现人群CBMN与甲醛接触量呈明显正相关(r=0.321,P<0.01).Logistics回归分析显示,甲醛累积接触量是接触工人高CBMN的危险因素(Ptrend=0.002).结论 血清FA-HSA能够用作内暴露指标评价甲醛接触工人的个体接触水平;甲醛的累积接触导致接触工人外周血淋巴细胞CBMN增加.
目的 探討職業性甲醛接觸對工人外週血淋巴細胞微覈率(CBMN)的影響.方法 選擇山東省某人造密度闆廠2箇有代錶性的車間,使用高效液相色譜法測定空氣甲醛濃度,採集236名工人的外週靜脈血,酶聯免疫分析法測定內暴露標誌物血清甲醛-白蛋白加閤物(FA-HSA)的含量,根據內暴露標誌物的三分位數將人群分為低、中、高水平3箇接觸組,用胞質分裂阻滯法微覈試驗檢測外週血淋巴細胞遺傳物質的損傷情況.結果 低甲醛接觸車間和高甲醛接觸車間的平均空氣甲醛含量分彆為(0.58:±-0.20)、(1.48±0.61)mg/m3,接觸工人血清中FA-HSA平均水平分彆為(69.22±15.37)、(136.29±89.49)pg/ml,差異均有統計學意義(P<0.01).低、中、高接觸組工人外週血淋巴細胞CBMN分彆為1.94‰±1.72%、2.10‰±1.92‰、2.10‰±1.70‰,各組間CBMN的差異無統計學意義(P>0.05).低、中、高纍積接觸水平組CBMN分彆為1.36‰±1.36%o、2.31o±:1.81‰、2.49‰±1.92‰,不同纍積接觸水平組工人外週血淋巴細胞CBMN的差異有統計學意義(P<0.01).Spearman相關分析髮現人群CBMN與甲醛接觸量呈明顯正相關(r=0.321,P<0.01).Logistics迴歸分析顯示,甲醛纍積接觸量是接觸工人高CBMN的危險因素(Ptrend=0.002).結論 血清FA-HSA能夠用作內暴露指標評價甲醛接觸工人的箇體接觸水平;甲醛的纍積接觸導緻接觸工人外週血淋巴細胞CBMN增加.
목적 탐토직업성갑철접촉대공인외주혈림파세포미핵솔(CBMN)적영향.방법 선택산동성모인조밀도판엄2개유대표성적차간,사용고효액상색보법측정공기갑철농도,채집236명공인적외주정맥혈,매련면역분석법측정내폭로표지물혈청갑철-백단백가합물(FA-HSA)적함량,근거내폭로표지물적삼분위수장인군분위저、중、고수평3개접촉조,용포질분렬조체법미핵시험검측외주혈림파세포유전물질적손상정황.결과 저갑철접촉차간화고갑철접촉차간적평균공기갑철함량분별위(0.58:±-0.20)、(1.48±0.61)mg/m3,접촉공인혈청중FA-HSA평균수평분별위(69.22±15.37)、(136.29±89.49)pg/ml,차이균유통계학의의(P<0.01).저、중、고접촉조공인외주혈림파세포CBMN분별위1.94‰±1.72%、2.10‰±1.92‰、2.10‰±1.70‰,각조간CBMN적차이무통계학의의(P>0.05).저、중、고루적접촉수평조CBMN분별위1.36‰±1.36%o、2.31o±:1.81‰、2.49‰±1.92‰,불동루적접촉수평조공인외주혈림파세포CBMN적차이유통계학의의(P<0.01).Spearman상관분석발현인군CBMN여갑철접촉량정명현정상관(r=0.321,P<0.01).Logistics회귀분석현시,갑철루적접촉량시접촉공인고CBMN적위험인소(Ptrend=0.002).결론 혈청FA-HSA능구용작내폭로지표평개갑철접촉공인적개체접촉수평;갑철적루적접촉도치접촉공인외주혈림파세포CBMN증가.
Objective To investigate the effects of occupational exposure to formaldehyde on the micronuclei frequencies in peripheral blood lymphocytes of workers.Methods Two hundred thirty six plywood workers were divided into 3 exposure groups(low,middle and high)according to internal exposure biomarker (formaldehyde human serum albumin conjugate,FA-HSA),which was detected by ELISA.The concentrations of formaldehyde(FA)in air of two workshops were measure using the high performance liquid chromatography.Cytokinesis-block micronucleus(CBMN)test was used to detect the micronuclei frequencies of peripheral blood lymphocyte in 236 workers.Results The average concentrations of FA in the low and high exposure workshops were 0.58±0.20 and 1.48±0.61 mg/m3,respectively,there was significant difference(P<0.01).The average concentrations of serum FA-HAS of workers in two workshops were 69.22±15.37 and 136.29±89.49 pg/ml,respectively,there was significant difference(P<0.01).The results of CBMN test showed that the micronucleus frequencies in low,middle and high exposure groups were 1.94± 1.72,2.10± 1.92 and 2.10± 1.70 ‰,respectively,there were no significant differences between groups.However,the micronucleus frequencies in accumulative low,middle and high exposure groups were 1.36±1.36,2.31 ±1.81 and 2.49±1.92 w,respectively,there were significant differences between different accumulative exposure groups(P<0.01).The results of correlation analysis indicated that there was a positive correlation between accumulative exposure levels and micronucleus frequencies(r,=0.321,P<0.01).The accumulative exposure doses may be a risk factor for high micronucleus frequencies in workers exposed to FA(Ptrend=0.002).Conclusion FA-HSA levels can serve as an internal exposure biomarker for assessing the exposure level of workers exposed to FA.Accumulative formaldehyde exposure resulted in an increase of micronuclei frequencies of peripheral blood lymphocyte in plywood workers.