国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2012年
2期
76-79,封3
,共5页
杨广德%郜玉峰%李旭%尹华发
楊廣德%郜玉峰%李旭%尹華髮
양엄덕%고옥봉%리욱%윤화발
趋化因子,CXC%多态性,单核苷酸%疾病遗传易感性%肝炎,乙型,慢性
趨化因子,CXC%多態性,單覈苷痠%疾病遺傳易感性%肝炎,乙型,慢性
추화인자,CXC%다태성,단핵감산%질병유전역감성%간염,을형,만성
Chemokine,CXC%Polymorphism,single nucleotide%Genetic susceptibility%Hepatitis B,chronic
目的 探讨IFN γ诱导蛋白10(CXCL10)单核苷酸多态性(SNP)位点rs4257674和rs4256246的多态性和中国人群慢性乙型肝炎(CHB)遗传易感性的关系.方法 采用多通道Snapshot分型技术检测501例CHB患者(CHB组)和301例自限性乙型肝炎者(对照组)CXCL10基因rs4257674和rs4256246的多态性,计算和分析基因型、等位基因频率和单体型频率.结果 CXCL10 rs4257674位点多态性在CHB组和对照组组中的等位基因频率(OR=2.347,95％CI:1.478～3.729,x2=13.763,P＜0.01)和基因型分布(x2=12.910,P＜0.01),差异有统计学意义；rs4256246位点多态性在CHB组和对照组中的基因型分布(x2=1.795,P＞0.05)、等位基因频率(OR=1.107,95％ CI:0.897～1.366,x2=0.899,P＞0.05)差异无统计学意义.rs4257674和rs4256246两位点构成的单体型C/T在CHB组和对照组频率分布差异有统计学意义(OR=2.139,95％CI:1.340～ 3.413,x2=10.597,P＜0.01)；单体型C/C、T/C频率分布在两组之间差异无统计学意义(x2C/C=0.262,x2T/C=1.342,P＞0.05)；单体型T/T频率＜0.03.结论 CXCL10基因多态性位点rs42.57674可能与中国人群CHB发病相关.
目的 探討IFN γ誘導蛋白10(CXCL10)單覈苷痠多態性(SNP)位點rs4257674和rs4256246的多態性和中國人群慢性乙型肝炎(CHB)遺傳易感性的關繫.方法 採用多通道Snapshot分型技術檢測501例CHB患者(CHB組)和301例自限性乙型肝炎者(對照組)CXCL10基因rs4257674和rs4256246的多態性,計算和分析基因型、等位基因頻率和單體型頻率.結果 CXCL10 rs4257674位點多態性在CHB組和對照組組中的等位基因頻率(OR=2.347,95％CI:1.478～3.729,x2=13.763,P＜0.01)和基因型分佈(x2=12.910,P＜0.01),差異有統計學意義；rs4256246位點多態性在CHB組和對照組中的基因型分佈(x2=1.795,P＞0.05)、等位基因頻率(OR=1.107,95％ CI:0.897～1.366,x2=0.899,P＞0.05)差異無統計學意義.rs4257674和rs4256246兩位點構成的單體型C/T在CHB組和對照組頻率分佈差異有統計學意義(OR=2.139,95％CI:1.340～ 3.413,x2=10.597,P＜0.01)；單體型C/C、T/C頻率分佈在兩組之間差異無統計學意義(x2C/C=0.262,x2T/C=1.342,P＞0.05)；單體型T/T頻率＜0.03.結論 CXCL10基因多態性位點rs42.57674可能與中國人群CHB髮病相關.
목적 탐토IFN γ유도단백10(CXCL10)단핵감산다태성(SNP)위점rs4257674화rs4256246적다태성화중국인군만성을형간염(CHB)유전역감성적관계.방법 채용다통도Snapshot분형기술검측501례CHB환자(CHB조)화301례자한성을형간염자(대조조)CXCL10기인rs4257674화rs4256246적다태성,계산화분석기인형、등위기인빈솔화단체형빈솔.결과 CXCL10 rs4257674위점다태성재CHB조화대조조조중적등위기인빈솔(OR=2.347,95％CI:1.478～3.729,x2=13.763,P＜0.01)화기인형분포(x2=12.910,P＜0.01),차이유통계학의의；rs4256246위점다태성재CHB조화대조조중적기인형분포(x2=1.795,P＞0.05)、등위기인빈솔(OR=1.107,95％ CI:0.897～1.366,x2=0.899,P＞0.05)차이무통계학의의.rs4257674화rs4256246량위점구성적단체형C/T재CHB조화대조조빈솔분포차이유통계학의의(OR=2.139,95％CI:1.340～ 3.413,x2=10.597,P＜0.01)；단체형C/C、T/C빈솔분포재량조지간차이무통계학의의(x2C/C=0.262,x2T/C=1.342,P＞0.05)；단체형T/T빈솔＜0.03.결론 CXCL10기인다태성위점rs42.57674가능여중국인군CHB발병상관.
Objective To investigate the association between two SNPs(rs4257674,rs4256246) in CXCL10 and the genetic susceptibility of Chinese people to chronic hepatitis B infection.Methods A case-control study of 501 Chinese cases of chronic hepatitis B(CHB) was perfonmed and 301 self-limiting HBV-infected individuals were selected as controls.SNPs in CXCL10(rs4257674,rs4256246)were genotyped with the Multiplex Snapshot technique.The genotype,allele and haplotype frequencies were calculated and analyzed.Results The SNP site rs4257674 showed a significant association with the two groups both in allelic analysis( OR =2.347,95％ CI:1.478-3.729,x2 =13.763,P ＜ 0.01 ) and in genotype analysis(x2 =12.910,P ＜ 0.01).The other SNP site rs4256246 was not related with two groups both in allelic analysis( OR =1.107,95％ CI:0.897-1.366,x2 =1.795,P ＞ 0.05) and in genotype analysis( x2 =0.899,P ＞ 0.05).C/T haplotype,generated by the two SNPs showed significantly difference between the two groups ( OR =2.139,95％CI:1.340-3.413,x2=10.597,P ＜ 0.01).C/C and T/C haplotypes showed no assosition between the two groups (x2C/C=0.262,x2T/C=1.342,P＞0.05).T/T haplotype frequency was less than 0.03.Conclusions The data suggests that the SNP site rs4257674 of CXCL10 may be associated with HBV infection in the Chinese population.
