中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2010年
5期
354-356
,共3页
陈有挺%石铮%陈志山%何庆良%林永堃
陳有挺%石錚%陳誌山%何慶良%林永堃
진유정%석쟁%진지산%하경량%림영곤
结肠肿瘤%A群链球菌制剂%化学疗法%预后
結腸腫瘤%A群鏈毬菌製劑%化學療法%預後
결장종류%A군련구균제제%화학요법%예후
Colonic neoplasms%Sapylin%Chemotherapy%Prognosis
目的 研究A群链球菌制剂联合化疗对结肠癌根治术后局部复发、肝转移及生存率的影响.方法 将2004年1月至2005年12月间行根治手术的132例Ⅱ期和Ⅲ期结肠癌患者,根据计算机产生的随机数字表将患者随机分成试验组60例(A群链球菌制剂联合腹腔灌注及全身静脉化疗)和对照组72例(单纯化疗,给药方式和化疗方案同试验组),比较两组患者的毒性反应、腹腔局部复发、肝转移率及生存率.结果 两组患者化疗期间不良反应的差异无统计学意义(P>0.05).试验组患者术后3年内有9例(15.0%)发生肝转移,11例(18.3%)出现局部复发,均低于对照组(30.6%和34.7%),差异具有统计学意义(均P<0.05).两组术后3年生存率分别为73.3%和54.2%,差异有统计学意义(P<0.05).结论 A群链球菌制剂联合腹腔灌注及全身静脉化疗可降低结肠癌根治术后局部复发和肝转移发生率,并提高术后生存率.
目的 研究A群鏈毬菌製劑聯閤化療對結腸癌根治術後跼部複髮、肝轉移及生存率的影響.方法 將2004年1月至2005年12月間行根治手術的132例Ⅱ期和Ⅲ期結腸癌患者,根據計算機產生的隨機數字錶將患者隨機分成試驗組60例(A群鏈毬菌製劑聯閤腹腔灌註及全身靜脈化療)和對照組72例(單純化療,給藥方式和化療方案同試驗組),比較兩組患者的毒性反應、腹腔跼部複髮、肝轉移率及生存率.結果 兩組患者化療期間不良反應的差異無統計學意義(P>0.05).試驗組患者術後3年內有9例(15.0%)髮生肝轉移,11例(18.3%)齣現跼部複髮,均低于對照組(30.6%和34.7%),差異具有統計學意義(均P<0.05).兩組術後3年生存率分彆為73.3%和54.2%,差異有統計學意義(P<0.05).結論 A群鏈毬菌製劑聯閤腹腔灌註及全身靜脈化療可降低結腸癌根治術後跼部複髮和肝轉移髮生率,併提高術後生存率.
목적 연구A군련구균제제연합화료대결장암근치술후국부복발、간전이급생존솔적영향.방법 장2004년1월지2005년12월간행근치수술적132례Ⅱ기화Ⅲ기결장암환자,근거계산궤산생적수궤수자표장환자수궤분성시험조60례(A군련구균제제연합복강관주급전신정맥화료)화대조조72례(단순화료,급약방식화화료방안동시험조),비교량조환자적독성반응、복강국부복발、간전이솔급생존솔.결과 량조환자화료기간불량반응적차이무통계학의의(P>0.05).시험조환자술후3년내유9례(15.0%)발생간전이,11례(18.3%)출현국부복발,균저우대조조(30.6%화34.7%),차이구유통계학의의(균P<0.05).량조술후3년생존솔분별위73.3%화54.2%,차이유통계학의의(P<0.05).결론 A군련구균제제연합복강관주급전신정맥화료가강저결장암근치술후국부복발화간전이발생솔,병제고술후생존솔.
Objective To evaluate the effect of Sapylin combined with intrapefitoneal and systemic chemotherapy for advanced colon cancer following radical operation on local recurrence,hepatic metastasis,and overall survival rate. Methods From Jan.2004 to Dec.2005,132 patients with stage Ⅱ or Ⅲ colon carcinoma after radical operation were randomly divided into two groups:Sapylin combined with chemotherapy(Sapylin)group and the control group.Toxic reaction,local recurrence,hepatic metastasis,and overall survival rate between two groups were compared. Results Both groups successfully completed the trial.There was no significant difference in toxic reaction between two groups.the recurrence and hepatic metastasis rate in Sapylin group were lower than those in the control group (9/60,15.0% vs.22/72,30.6%;11/60,18.3% vs.22/72,34.7%,respectively),which were statistically significant(P<0.05 respectively).The 3-year survival rate in Sapylin group was higher than that in control group (73.3%vs.54.2%),which was statistically significant (P<0.05). Conclusion Sapylin combined with intraperitoneal and systemic chemotherapy can effectively decrease local recurrence and hepmic metastasis,and improve the survival in patients with advanced colon cancer following radical operation.