CAJ | 학술논문

目的研究肾综合征出血热(HFRS)疫苗远期保护率,分析疫苗接种后抗体变化规律.方法采取整群、随机抽样和横断面调查方法,在陕西省HFRS疫区(户县)和非疫区(定边县)开展发病和疫苗接种调查,采用ELISA检测血清IgG抗体.结果 HFRS疫苗保护率拟合接种年限的曲线方程[保护率Y=(0.863+ 0.283/X年限)×100％],末次接种7～8年后保护率降到90％以下,10年后为88％,平均94％；疫区接种人群IgG检测吸光度(A)中位数高于疫区非接种人群4倍,完成基础免疫接种即可获得较高抗体水平,末次接种5～ 10年间抗体水平下降50％,10年以后下降60％.结论在HFRS疫区,人群抗体在末次接种后5～10年间下降50％,疫苗保护率在7～8年后降到90％以下,可考虑7年后再加强接种一个针次.
목적 연구신종합정출혈열(HFRS)역묘원기보호솔,분석역묘접충후항체변화규률.방법 채취정군、수궤추양화횡단면조사방법,재합서성HFRS역구(호현)화비역구(정변현)개전발병화역묘접충조사,채용ELISA검측혈청IgG항체.결과 HFRS역묘보호솔의합접충년한적곡선방정[보호솔Y=(0.863+ 0.283/X년한)×100％],말차접충7～8년후보호솔강도90％이하,10년후위88％,평균94％；역구접충인군IgG검측흡광도(A)중위수고우역구비접충인군4배,완성기출면역접충즉가획득교고항체수평,말차접충5～ 10년간항체수평하강50％,10년이후하강60％.결론 재HFRS역구,인군항체재말차접충후5～10년간하강50％,역묘보호솔재7～8년후강도90％이하,가고필7년후재가강접충일개침차.
Objective To evaluate the protective rate and the variation of HFRS-IgG on hemorrhagical fever with renal syndrome (HFRS) vaccine.Methods Cluster,random sampling and cross-sectional study were used to assess the protective rate of HFRS vaccination.Level of HFRS-IgG was detected with ELISA in epidemic and non-epidemic areas of HFRS.Results Curve equation was obtained as Yprocective rate=(0.863+0.283/Xvaccination term) × 100％ by protective rate with vaccination term.Protective rates showed a reducing trend,90％ after 7-8 years of vaccination,88％ after 10 years,and 94％ on average.Absorbance (A) value of HFRS-IgG was 4 times higher in persons with vaccination than those without,in the epidemic area.Higher antibody level could be obtained after primary vaccination,but the level of antibody had a 50％ reduction after 5-10 years of vaccination,and a 60％ reduction after 10 years of vaccination.Conclusion HFRS antibody had a 50％ reduction after 5-10 years of vaccination.The protective rate of HFRS vaccination had a 90％ loss,after 7-8 years of vaccination.Booster dose was necessary after 7 years of vaccination.