CAJ | 학술논문

目的分析原发韦氏环黏膜相关淋巴组织(MALT)淋巴瘤的临床特点和长期治疗结果.方法回顾分析本院初治的10例原发韦氏环MALT淋巴瘤,其中男1例、女9例,ⅠE期7例、ⅡE期3例.单纯放疗3例,7例在放疗前加1～4周期化疗或再加辅助化疗.放疗中位剂量40 Gy,化疗方案以CHOP方案为主.结果中位年龄58岁,均无全身症状,只有1例乳酸脱氢酶升高.疗后完全缓解率100％.中位随访90个月,全组5年总生存率、疾病相关生存率和无进展生存率分别为90％、100％和80％.1例死于直肠癌肝转移,1例脑部复发经放疗挽救治愈.结论韦氏环MALT淋巴瘤与其他胃外MALT淋巴瘤有类似临床特点,放疗为主的治疗取得了出色的长期疗效.
목적 분석원발위씨배점막상관림파조직(MALT)림파류적림상특점화장기치료결과.방법 회고분석본원초치적10례원발위씨배MALT림파류,기중남1례、녀9례,ⅠE기7례、ⅡE기3례.단순방료3례,7례재방료전가1～4주기화료혹재가보조화료.방료중위제량40 Gy,화료방안이CHOP방안위주.결과 중위년령58세,균무전신증상,지유1례유산탈경매승고.료후완전완해솔100％.중위수방90개월,전조5년총생존솔、질병상관생존솔화무진전생존솔분별위90％、100％화80％.1례사우직장암간전이,1례뇌부복발경방료만구치유.결론 위씨배MALT림파류여기타위외MALT림파류유유사림상특점,방료위주적치료취득료출색적장기료효.
Objective To investigate the clinical characteristics and long-term outcome of patients with mucosa-associated lymphoid tissue ( MALT) lymphoma of Waldeyer's ring. Methods Ten patients were retrospectively analyzed. Seven patients had stage ⅠE and 3 patients had stage ⅡE disease. All patients received radiation therapy with a median dose of 40 Gy, and 7 patients also received 1 t0 4 cycles of CHOP-based chemotherapy before radiation. Results The ratio of male to　female was 1∶9. The median age was 58 years. No patient had B symptoms. One patient had elevated LDH level. The complete response rate after treatment was 100％. With median follow-up periods of 90 months, 1 patient died from rectal cancer. One patient developed brain metastasis and was salvaged by radiotherapy. The 5-year overall survival, cancer specific survival and progression-free survival rates were 90％ , 100％ and 80％ , respectively. Conclusions The clinical characteristics of Waldeyer's ring MALT lymphoma were similar to that of nongastric MALT lymphoma. For patients with Waldeyer's ring MALT lymphoma, primary radiotherapy can result in excellent long-term survival.