CAJ | 학술논문

目的探讨EG-1基因在乳腺癌组织中的表达及其与乳腺癌临床特征、预后的相关性.方法采用RT-PCR技术,检测EG-1基因在72例乳腺癌及18例良性乳腺组织中的表达,分析其表达与临床特征及预后的相关性.结果 71%(51/72)患者的乳腺癌石蜡标本中EG-1mRNA阳性,而良性乳腺组织中的表达率为24%(4/18).EG-1基因在乳腺癌组织中的表达与淋巴结转移、VEGF蛋白有关(P＜0.05),与年龄、月经状况、肿瘤大小、组织学分级、Her-2蛋白、p53蛋白、激素受体状况无关,EG-1mRNA阳性患者远处转移率和复发率高于阴性患者.多因素回归分析发现EG-1mRNA阳性是乳腺癌的独立预后因素之一. 结论 EG-1基因在乳腺癌组织中异常高表达,且与淋巴结转移及VEGF蛋白相关,是乳腺癌潜在的预后标记物.
목적 탐토EG-1기인재유선암조직중적표체급기여유선암림상특정、예후적상관성.방법 채용RT-PCR기술,검측EG-1기인재72례유선암급18례량성유선조직중적표체,분석기표체여림상특정급예후적상관성.결과 71%(51/72)환자적유선암석사표본중EG-1mRNA양성,이량성유선조직중적표체솔위24%(4/18).EG-1기인재유선암조직중적표체여림파결전이、VEGF단백유관(P＜0.05),여년령、월경상황、종류대소、조직학분급、Her-2단백、p53단백、격소수체상황무관,EG-1mRNA양성환자원처전이솔화복발솔고우음성환자.다인소회귀분석발현EG-1mRNA양성시유선암적독립예후인소지일. 결론 EG-1기인재유선암조직중이상고표체,차여림파결전이급VEGF단백상관,시유선암잠재적예후표기물.
Objective To investigate the correlation between the expression of EG-1 in breast cancer and the clinicopathological factors and prognosis of breast cancer.Methods EG-1 mRNA expression in 72 malignant and 18 benign breast tissues were evaluated by RT-PCR method,and its correlation with clinical characteristics and prognosis were retrospectively analyzed.Results EG-1 expression level was higher in malignant tissue than in the corresponding benign breast tissue(71%vs.24%,P＜0.05).EG-1 expression was significantly correlated with lymph node metastasis and protein VEGF (P＜0.05)and was not significantly with age,menopause,tnmor size,grade,hormone status,protein Her2 and pS3.The metastastic rate and recurrence rate in EG-1 positive patients was higher than that in EG-1 negative patients.Multivariate Cox model showed that EG-1 positive was an independent factor affecting overall survival and disease free survival.Conclusions EG-1 expression was up-regulated in breast cancer and significantly correlated with lymph node metastasis and protein VEGF.