中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
2期
160-162
,共3页
糖调节异常%血尿酸%血压%血脂
糖調節異常%血尿痠%血壓%血脂
당조절이상%혈뇨산%혈압%혈지
Impaired glucose regulation%Serum uric acid%Blood pressure%Lipids
目的 探讨糖调节异常者血尿酸水平与血脂、血压水平的关系.方法 从青岛地区糖尿病和高尿酸血症流行病学调查数据库中选取730例资料完整者进行分析.730例中糖调节异常高尿酸者106例,为A组；糖调节异常正常尿酸者173例,为B组；正常糖耐量高尿酸者103例,为C组；正常糖耐量正常尿酸者348例为D组,记录各组纳入分析者身高、体重、腰围、臀围、血压.采集清晨空腹静脉血,测定血糖、血尿酸、TC、TG、HDL-C等,并行75 g葡萄糖耐量试验测定负荷后2h血糖.结果 ①各组间血尿酸水平由高到低的顺序为A组、C组、B组、D组[ (450±72)、(434±59)、(324±51)、(311±52)μmol/L],差异有统计学意义(P ＜0.05或P＜0.01)；②各组TG、TC、SBP由高到低的顺序为A组、C组、B组、D组[TG:(1.85±0.10)、(1.81 ±0.10)、(1.45±0.10)、(1.43±0.10) mmol/L;TC:(5.72±0.10)、(5.60±0.10)、(5.42±0.10)、(5.12±0.10) mmol/L; SBP:( 142±20)、(138±21)、(135±176)、(125±19)mmHg,1 mmHg =0.133 kPa],差异有统计学意义(P ＜0.05或P＜0.01)；③以糖调节异常者TG、TC为因变量,以年龄、性别、BMI、腰围、血尿酸水平为自变量,进行多元线性回归,血尿酸水平未进入回归方程.以SBP为因变量,以年龄、性别、BMI、腰围、血尿酸水平为自变量,进行多元线性回归,血尿酸水平进入回归方程,差异有统计学意义(P ＜0.05或P＜0.01).结论 糖调节异常高尿酸血症者易合并血脂紊乱和高血压,且高尿酸血症可能是糖调节异常者高血压的独立危险因素,可促进其高血压恶化.
目的 探討糖調節異常者血尿痠水平與血脂、血壓水平的關繫.方法 從青島地區糖尿病和高尿痠血癥流行病學調查數據庫中選取730例資料完整者進行分析.730例中糖調節異常高尿痠者106例,為A組；糖調節異常正常尿痠者173例,為B組；正常糖耐量高尿痠者103例,為C組；正常糖耐量正常尿痠者348例為D組,記錄各組納入分析者身高、體重、腰圍、臀圍、血壓.採集清晨空腹靜脈血,測定血糖、血尿痠、TC、TG、HDL-C等,併行75 g葡萄糖耐量試驗測定負荷後2h血糖.結果 ①各組間血尿痠水平由高到低的順序為A組、C組、B組、D組[ (450±72)、(434±59)、(324±51)、(311±52)μmol/L],差異有統計學意義(P ＜0.05或P＜0.01)；②各組TG、TC、SBP由高到低的順序為A組、C組、B組、D組[TG:(1.85±0.10)、(1.81 ±0.10)、(1.45±0.10)、(1.43±0.10) mmol/L;TC:(5.72±0.10)、(5.60±0.10)、(5.42±0.10)、(5.12±0.10) mmol/L; SBP:( 142±20)、(138±21)、(135±176)、(125±19)mmHg,1 mmHg =0.133 kPa],差異有統計學意義(P ＜0.05或P＜0.01)；③以糖調節異常者TG、TC為因變量,以年齡、性彆、BMI、腰圍、血尿痠水平為自變量,進行多元線性迴歸,血尿痠水平未進入迴歸方程.以SBP為因變量,以年齡、性彆、BMI、腰圍、血尿痠水平為自變量,進行多元線性迴歸,血尿痠水平進入迴歸方程,差異有統計學意義(P ＜0.05或P＜0.01).結論 糖調節異常高尿痠血癥者易閤併血脂紊亂和高血壓,且高尿痠血癥可能是糖調節異常者高血壓的獨立危險因素,可促進其高血壓噁化.
목적 탐토당조절이상자혈뇨산수평여혈지、혈압수평적관계.방법 종청도지구당뇨병화고뇨산혈증류행병학조사수거고중선취730례자료완정자진행분석.730례중당조절이상고뇨산자106례,위A조；당조절이상정상뇨산자173례,위B조；정상당내량고뇨산자103례,위C조；정상당내량정상뇨산자348례위D조,기록각조납입분석자신고、체중、요위、둔위、혈압.채집청신공복정맥혈,측정혈당、혈뇨산、TC、TG、HDL-C등,병행75 g포도당내량시험측정부하후2h혈당.결과 ①각조간혈뇨산수평유고도저적순서위A조、C조、B조、D조[ (450±72)、(434±59)、(324±51)、(311±52)μmol/L],차이유통계학의의(P ＜0.05혹P＜0.01)；②각조TG、TC、SBP유고도저적순서위A조、C조、B조、D조[TG:(1.85±0.10)、(1.81 ±0.10)、(1.45±0.10)、(1.43±0.10) mmol/L;TC:(5.72±0.10)、(5.60±0.10)、(5.42±0.10)、(5.12±0.10) mmol/L; SBP:( 142±20)、(138±21)、(135±176)、(125±19)mmHg,1 mmHg =0.133 kPa],차이유통계학의의(P ＜0.05혹P＜0.01)；③이당조절이상자TG、TC위인변량,이년령、성별、BMI、요위、혈뇨산수평위자변량,진행다원선성회귀,혈뇨산수평미진입회귀방정.이SBP위인변량,이년령、성별、BMI、요위、혈뇨산수평위자변량,진행다원선성회귀,혈뇨산수평진입회귀방정,차이유통계학의의(P ＜0.05혹P＜0.01).결론 당조절이상고뇨산혈증자역합병혈지문란화고혈압,차고뇨산혈증가능시당조절이상자고혈압적독립위험인소,가촉진기고혈압악화.
Objective To investigate the relationship between serum uric acid (SUA),blood pressure and lipids in people with impaired glucose regulation.Methods The study had normal glucose tolerance (NGT) ( n =451 ) and impaired glucose regulation (IGR) ( n =279) patients.All participants had a questionnaire; levels of serum UA,totalcholesterol( TC ),Triglyceride ( TG),high density lipoprotein cholesterol ( HDL-C ) and fasting blood glucose (FBG) was measured.A standard 75g oral glucose torlerance test was performed in all the participants.Results The trend of SUA change in between-group was significant [ ( A group,C group,B group,D group) ; P ＜ 0.05 or P ＜0.01 ] ; after adjusting age,sex,body mass index( BMI),FBG,fasting blood glucose( PBG),the changing of TC,TG,SBP in between-group was significant [ A group,C group,B group,D group TG:( 1.85 ± 0.10),( 1.81 ±0.10),(1.45 ±0.10),(1.43 ±0.10)mmol/L;TC:(5.72 ±0.10),(5.60 ±0.10),(5.42 ±0.10),(5.12 ±0.10) mmol/L;SBP:( 142 ± 20),( 138 ± 21 ),( 135 ± 176),( 125 ± 19) mm Hg,1 mm Hg =0.133 kPa; P ＜ 0.05 or P ＜ 0.01 ] ; levels of SUA were independent risk factors for hypertension in people with impaired glucose regulation,but levels of SUA were unable.Conclusions Hyperuricemia people with impaired glucose regulation can suffer from hypertension and abnormal of blood lipid levels.Hyperuricemia may be an indepentdent risk factor which causes hypertension in people with impaired glucose regulation.
