中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2008年
9期
518-520
,共3页
卢艳慧%陆菊明%王淑玉%李春霖%刘力生%郑润平%田慧%王先令%杨丽娟%张育青%潘长玉
盧豔慧%陸菊明%王淑玉%李春霖%劉力生%鄭潤平%田慧%王先令%楊麗娟%張育青%潘長玉
로염혜%륙국명%왕숙옥%리춘림%류력생%정윤평%전혜%왕선령%양려연%장육청%반장옥
空腹血糖受损%糖耐量减低%胰岛素抵抗%胰岛β细胞功能
空腹血糖受損%糖耐量減低%胰島素牴抗%胰島β細胞功能
공복혈당수손%당내량감저%이도소저항%이도β세포공능
Islet β cell function
目的 评价糖调节受损(IGR)不同组分的胰岛素抵抗(IR)和胰岛β细胞功能状况.方法 OGTT筛查北京地区无DM史中老年人群,据2003年ADA标准,分为正常糖耐量(NGT)组、空腹血糖受损(IFG)组、糖耐量减低(IGT)组、及IFG合并IGT(1FG+IGT)组,检测各组胰岛素抵抗指数(HO-MA-IR)、胰岛素敏感指数(ISI-Stumvoll)、β细胞功能指数(HBCI/IR)及第一,二时相胰岛素分泌指数.结果 (1)IFG组:HOMA-IR显著高于NGT组和IGT组,ISI-Stumvoll高于IGT组(P均<0.05),HBCI/IR显著低于NGT组和IGT组(P<0.05),(2)IGT组:HOMA-IR和HBCI/IR均位于NGT组和IFG组之间,ISI-Stumvoll、第一时相和第二时相胰岛素分泌指数显著低于NGT组和IFG组(P均<0.05);(3)IFG+IGT组:HOMA-IR高于NGT组、IFG组和IGT组,ISI-StumvoU显著低于NGT组和IFG组(P均<0.05),HBCI/lR显著低于NGT组和IGT组(P均＜0.05);(4)在非糖尿病人群中,随着FPG及2hPG的升高,HOMA-IR有递增趋势,ISI-Stumvoll、第一时相和第二时相胰岛素分泌指数有递减趋势(P均<0.05).结论 IFG主要是肝脏IR和基础状态时的胰岛β细胞分泌功能受损.IGT的肌肉IR较重,其糖负荷后的胰岛β细胞分泌功能受损较重.在非糖尿病人群,FPG和2hPG的升高与IR呈正相关,与胰岛β细胞功能呈负相关.
目的 評價糖調節受損(IGR)不同組分的胰島素牴抗(IR)和胰島β細胞功能狀況.方法 OGTT篩查北京地區無DM史中老年人群,據2003年ADA標準,分為正常糖耐量(NGT)組、空腹血糖受損(IFG)組、糖耐量減低(IGT)組、及IFG閤併IGT(1FG+IGT)組,檢測各組胰島素牴抗指數(HO-MA-IR)、胰島素敏感指數(ISI-Stumvoll)、β細胞功能指數(HBCI/IR)及第一,二時相胰島素分泌指數.結果 (1)IFG組:HOMA-IR顯著高于NGT組和IGT組,ISI-Stumvoll高于IGT組(P均<0.05),HBCI/IR顯著低于NGT組和IGT組(P<0.05),(2)IGT組:HOMA-IR和HBCI/IR均位于NGT組和IFG組之間,ISI-Stumvoll、第一時相和第二時相胰島素分泌指數顯著低于NGT組和IFG組(P均<0.05);(3)IFG+IGT組:HOMA-IR高于NGT組、IFG組和IGT組,ISI-StumvoU顯著低于NGT組和IFG組(P均<0.05),HBCI/lR顯著低于NGT組和IGT組(P均＜0.05);(4)在非糖尿病人群中,隨著FPG及2hPG的升高,HOMA-IR有遞增趨勢,ISI-Stumvoll、第一時相和第二時相胰島素分泌指數有遞減趨勢(P均<0.05).結論 IFG主要是肝髒IR和基礎狀態時的胰島β細胞分泌功能受損.IGT的肌肉IR較重,其糖負荷後的胰島β細胞分泌功能受損較重.在非糖尿病人群,FPG和2hPG的升高與IR呈正相關,與胰島β細胞功能呈負相關.
목적 평개당조절수손(IGR)불동조분적이도소저항(IR)화이도β세포공능상황.방법 OGTT사사북경지구무DM사중노년인군,거2003년ADA표준,분위정상당내량(NGT)조、공복혈당수손(IFG)조、당내량감저(IGT)조、급IFG합병IGT(1FG+IGT)조,검측각조이도소저항지수(HO-MA-IR)、이도소민감지수(ISI-Stumvoll)、β세포공능지수(HBCI/IR)급제일,이시상이도소분비지수.결과 (1)IFG조:HOMA-IR현저고우NGT조화IGT조,ISI-Stumvoll고우IGT조(P균<0.05),HBCI/IR현저저우NGT조화IGT조(P<0.05),(2)IGT조:HOMA-IR화HBCI/IR균위우NGT조화IFG조지간,ISI-Stumvoll、제일시상화제이시상이도소분비지수현저저우NGT조화IFG조(P균<0.05);(3)IFG+IGT조:HOMA-IR고우NGT조、IFG조화IGT조,ISI-StumvoU현저저우NGT조화IFG조(P균<0.05),HBCI/lR현저저우NGT조화IGT조(P균＜0.05);(4)재비당뇨병인군중,수착FPG급2hPG적승고,HOMA-IR유체증추세,ISI-Stumvoll、제일시상화제이시상이도소분비지수유체감추세(P균<0.05).결론 IFG주요시간장IR화기출상태시적이도β세포분비공능수손.IGT적기육IR교중,기당부하후적이도β세포분비공능수손교중.재비당뇨병인군,FPG화2hPG적승고여IR정정상관,여이도β세포공능정부상관.
Objective To analyze the islet β cell function and the insulin resistance of different components of impaired glucose regulation(IGR).Methods A total of 463 adults diagnosed as IGR and 200 adults diagnosed as NGT by 75g OGTT,were included for the analysis of the islet beta cell function and insulin resistance.Results In the IFG group,HOMA-IR was significantly higher than in NGT and IGT group(P<0.05),ISI-Stumvoll was lower than in NGT group,but higher than in IGT group(P<0.05);HBCI/IR were lower than in the two groups(P<0.05).HOMA-IR and HBCI/IR of IGT group were between the NGT group and the IFG group.ISI-Stumvoll,the first and second phase insulin secretion index were significantly lower in IGT group than in NGT group and IFG group(P<0.05).In the IFG plus IGT group,HOMA-IR was the highest among all the groups;ISI-Stumvoll was lower than the NGT group and the IFG group;HBCI/IR were lower than the NGT group and the IGT group;the first and second phase insulin secretion index were the lowest among all the groups.In the non-diabetic population,along with the increasing of fasting plasma glucose(FPG) or 2h plasma glucose(2hPG),HOMA-IR was increased gradually,ISI-Stumvoll and the first and second phase insulin secretion indexes were decreased gradually(P<0.05).Conclusions IFG is originatd from severe hepatic insulin resistance and basal islet β cell dysfunction.IGT is originated from marked peripheral insulin resistance,and post-glucose-loading β cell dysfunction with near-normal basal insulin secretion.In the non-diabetic groups,FPG and 2hPG are positively correlated with insulin resistance,and negatively correlated with islet β cell function
