中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2008年
10期
1678-1679,插3
,共3页
麻醉药%联用%剂量效应关系,药物%丙泊酚%异氟烷
痳醉藥%聯用%劑量效應關繫,藥物%丙泊酚%異氟烷
마취약%련용%제량효응관계,약물%병박분%이불완
Anesthetics,combinod%Does-response relationship,drug%Propofol%Isoflurane
目的 研究丙泊酚与异氟烷在平衡麻醉中的剂量-效应关系.方法 择期平衡麻醉30例,以丙泊酚1.5 mg/ks、维库溴铵0.12 mg/ks、芬太尼2～4 μg/kg诱导气管插管,以维库溴铵1.2μg?kg-1?min-1、芬太尼2μg?kg-1?h-1持续恒速泵入维持麻醉(直至手术结束前20 min).逐渐减小异氟烷浓度、增加丙泊酚剂量,使各平衡点的BIS值始终维持于50～60之间,记录各平衡点的异氟烷浓度/丙泊酚泵注剂量(并利用SPSS软件绘制散点图)、平均动脉压(MAP)(mm Hg)、心率等.结果 丙泊酚剂量、异氟烷浓度问的关系符合指数曲线模型,其曲线方程式为Y=102.991×exp(-1.4456x),判定系数R2=0.784;丙泊酚最大剂量与异氟烷最大浓度间的比值为54/1.当仅依靠异氟烷吸入维持BIS值于50～60时,MAP较基础值下降明显(P<0.05),随着异氟烷吸入浓度的下降、丙泊酚泵注剂量的增加,各平衡点的MAP、心率渐呈上升趋势,但与麻醉前相比,差异无统计学意义(P>0.05).结论 当BIS维持于50～60时,丙泊酚剂量与异氟烷浓度之间符合指数曲线模型,合理应用丙泊酚可有效降低异氟烷的循环抑制作用.
目的 研究丙泊酚與異氟烷在平衡痳醉中的劑量-效應關繫.方法 擇期平衡痳醉30例,以丙泊酚1.5 mg/ks、維庫溴銨0.12 mg/ks、芬太尼2～4 μg/kg誘導氣管插管,以維庫溴銨1.2μg?kg-1?min-1、芬太尼2μg?kg-1?h-1持續恆速泵入維持痳醉(直至手術結束前20 min).逐漸減小異氟烷濃度、增加丙泊酚劑量,使各平衡點的BIS值始終維持于50～60之間,記錄各平衡點的異氟烷濃度/丙泊酚泵註劑量(併利用SPSS軟件繪製散點圖)、平均動脈壓(MAP)(mm Hg)、心率等.結果 丙泊酚劑量、異氟烷濃度問的關繫符閤指數麯線模型,其麯線方程式為Y=102.991×exp(-1.4456x),判定繫數R2=0.784;丙泊酚最大劑量與異氟烷最大濃度間的比值為54/1.噹僅依靠異氟烷吸入維持BIS值于50～60時,MAP較基礎值下降明顯(P<0.05),隨著異氟烷吸入濃度的下降、丙泊酚泵註劑量的增加,各平衡點的MAP、心率漸呈上升趨勢,但與痳醉前相比,差異無統計學意義(P>0.05).結論 噹BIS維持于50～60時,丙泊酚劑量與異氟烷濃度之間符閤指數麯線模型,閤理應用丙泊酚可有效降低異氟烷的循環抑製作用.
목적 연구병박분여이불완재평형마취중적제량-효응관계.방법 택기평형마취30례,이병박분1.5 mg/ks、유고추안0.12 mg/ks、분태니2～4 μg/kg유도기관삽관,이유고추안1.2μg?kg-1?min-1、분태니2μg?kg-1?h-1지속항속빙입유지마취(직지수술결속전20 min).축점감소이불완농도、증가병박분제량,사각평형점적BIS치시종유지우50～60지간,기록각평형점적이불완농도/병박분빙주제량(병이용SPSS연건회제산점도)、평균동맥압(MAP)(mm Hg)、심솔등.결과 병박분제량、이불완농도문적관계부합지수곡선모형,기곡선방정식위Y=102.991×exp(-1.4456x),판정계수R2=0.784;병박분최대제량여이불완최대농도간적비치위54/1.당부의고이불완흡입유지BIS치우50～60시,MAP교기출치하강명현(P<0.05),수착이불완흡입농도적하강、병박분빙주제량적증가,각평형점적MAP、심솔점정상승추세,단여마취전상비,차이무통계학의의(P>0.05).결론 당BIS유지우50～60시,병박분제량여이불완농도지간부합지수곡선모형,합리응용병박분가유효강저이불완적순배억제작용.
Objective To study the dose-response relationship between propofol and isoflurane in balanced anaesthesia. Methods 30 patients, age ranged from 46 to 68 years and body weight from 48 to 72 kilograms, were se-lected. Anaesthesia was induced with propofol 1.5mg/kg,vecuroniura 0.12 mg/kg, fentanyl 2～4μg/kg,and main-rained with vecuronium 1.2μg/kg,fentanyl 2μg/kg. Isoflurane was inhaled at first so that BIS could be maintained on the level of 50～60. Then, minishing the isoflurane concentration by 0.3%～0.5 % and adding the dosage of propofol synchronously, establishing 4～6 balanced level spots of anaesthesia, which could maintain BIS on the level of 50～60 all the time. Recording the isoflurane concentration, the dosage of propofol, MAP, HR, etc, and making the scatterplot graph in virtue of SPSS software. Results The relationship between propofol and isoflurane was accordance with ex-ponential curve model,of which the equation is :y= 102.991 x exp (-1.4456x), R2= 0.784 ; and the ratio of their dosages is 54/1. When isoflurane was inhaled alone at first, MAP was decreased significantly ( P<0.05 ). As the isoflurane concentration minished and the dosage of propofol added, MAP and HR were increasing gradually, but when isoflurane concentration was minished to zero, there is no significant difference as compared with the preanesthesia baseline ( P>0.05 ). Conclusion When BIS was on the balanced level of 50～60, exponential curve relationship ex-ists between the dosage of propofol and isoflurane concentration. If applied reasonabhly, propofol could be good for re-ducing circulation aide-effect of isoflurane.
