CAJ | 학술논문

危重症患儿在应激状态下可出现应激性高血糖,而持续的高血糖可以引起一系列的有害后果.目前认为应激性高血糖的机制与危重症患儿在应激时神经内分泌的改变有关.危重疾病时发生胰岛素抵抗可能与胰岛素受体功能异常、受体后信号转导、葡萄糖转运及细胞内代谢障碍等因素有关.应激性高血糖治疗原则为积极治疗原发病,同时应通过严格控制补液以控制高糖性高渗状态.
위중증환인재응격상태하가출현응격성고혈당,이지속적고혈당가이인기일계렬적유해후과.목전인위응격성고혈당적궤제여위중증환인재응격시신경내분비적개변유관.위중질병시발생이도소저항가능여이도소수체공능이상、수체후신호전도、포도당전운급세포내대사장애등인소유관.응격성고혈당치료원칙위적겁치료원발병,동시응통과엄격공제보액이공제고당성고삼상태.
In case of stress state,critically ill children may present hyperglycemia,and persistent hyperglycemia may cause harmful consequence. At present,the mechanism of stress hyperglycemia is believed to be associated with the changes of neuroendocrine. Insulin resistance in critical illness may be related to in-sulin receptor dysfunction, insulin post-receptor signal transduction abnormality ,aberrant glucose transport, in-tracellular metabolic dysfunction and so on. The therapeutic principles of stress hypergiycemia mainly rely on effective treatment of primary disease, and furthermore, simultaneous control of hyperglycemia and hyperos-mosis by strict control of fluid replacement is very important.