CAJ | 학술논문

环境内分泌干扰物是普遍存在于环境中的一类化学物质,能够造成机体内分泌系统功能紊乱.环境内分泌干扰物易被机体吸收而不易排出,相互之间具有协同作用,且具有遗传性及传代性,因此能严重影响人类的健康.环境内分泌干扰物可以导致下丘脑-垂体-性腺轴形态和功能的改变,影响其调节功能;干扰雌激素的代谢及转运,提高体内雌激素水平;激活雌激素受体,增强其敏感性,从而导致青春期发育提前.
배경내분비간우물시보편존재우배경중적일류화학물질,능구조성궤체내분비계통공능문란.배경내분비간우물역피궤체흡수이불역배출,상호지간구유협동작용,차구유유전성급전대성,인차능엄중영향인류적건강.배경내분비간우물가이도치하구뇌-수체-성선축형태화공능적개변,영향기조절공능;간우자격소적대사급전운,제고체내자격소수평;격활자격소수체,증강기민감성,종이도치청춘기발육제전.
Environmental endocrine disruptors are pollutants of many chemical classes,which are ubiquitous and persistent in the environment and can exert adverse effects on the endocrine system. Environmental endocrine disruptors are easily absorbed by the body, but not excreted. They are synergistic and hereditary. Therefore,environmental endocrine disruptors will severely destroy public health. Environmental endocrine disruptors, bringing about changes in morphology and function of the hypothalamus-pituitary-gonadal axis, interfering with the metabolism and transportation of estrogen, improve estrogen levels. They can activate estrogen receptor and enhance its sensitivity. By these means, environmental endocrine disruptors lead to early puberty development.