国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
4期
258-260
,共3页
调节性B细胞%自身免疫性糖尿病%白细胞介素-10%转化生长因子-β1
調節性B細胞%自身免疫性糖尿病%白細胞介素-10%轉化生長因子-β1
조절성B세포%자신면역성당뇨병%백세포개소-10%전화생장인자-β1
Regulatory B cells%Autoimmune diabetes mellitus%Interleukin-10%Transforming growth factor-β1
调节性B细胞在自身免疫性糖尿病的发生、发展、转归过程中起重要调节作用.通过产生白细胞介素-10(IL-10)和转化生长因子-β1(TGF-β1)等抑制性细胞因子介导免疫耐受.体外诱导分泌TGF-β1的调节性B细胞可以为自身免疫性糖尿病的治疗提供新的方法.抗CD20单克隆抗体治疗自身免疫性糖尿病可使调节性B细胞数量增加.
調節性B細胞在自身免疫性糖尿病的髮生、髮展、轉歸過程中起重要調節作用.通過產生白細胞介素-10(IL-10)和轉化生長因子-β1(TGF-β1)等抑製性細胞因子介導免疫耐受.體外誘導分泌TGF-β1的調節性B細胞可以為自身免疫性糖尿病的治療提供新的方法.抗CD20單剋隆抗體治療自身免疫性糖尿病可使調節性B細胞數量增加.
조절성B세포재자신면역성당뇨병적발생、발전、전귀과정중기중요조절작용.통과산생백세포개소-10(IL-10)화전화생장인자-β1(TGF-β1)등억제성세포인자개도면역내수.체외유도분비TGF-β1적조절성B세포가이위자신면역성당뇨병적치료제공신적방법.항CD20단극륭항체치료자신면역성당뇨병가사조절성B세포수량증가.
Regulatory B cells(Bregs) play important roles in the occurrence,development and outcomes of autoimmune diabetes.They secrete suppressive cytokines such as interleukin-10 (IL-10) and transforming growth factor-β1 ( TGF-β1 ) to induce immunologic tolerance.Bregs inducing TGF-β1 secretion in vitro provides a new treatment of autoimmune diabetes.When using anti-CD20 monoclonal antibody to treat autoimmune diabetes,there is an increase in Bregs population.
