CAJ | 학술논문

自噬是细胞内溶酶体/内体参与的,涉及细胞增殖,分化及稳态平衡调节的降解过程.遗传学研究发现其在物种进化过程中较保守,从酵母到哺乳动物细胞中均有自噬相关基因的存在,提示自噬广泛参与各类生物正常的生理过程.近年来,随着研究的不断深入,人们发现自噬在许多疾病尤其在免疫相关疾病中亦扮演着重要角色,在感染,自身免疫,肿瘤免疫中所起的作用可为今后研究提供依据.
자서시세포내용매체/내체삼여적,섭급세포증식,분화급은태평형조절적강해과정.유전학연구발현기재물충진화과정중교보수,종효모도포유동물세포중균유자서상관기인적존재,제시자서엄범삼여각류생물정상적생리과정.근년래,수착연구적불단심입,인문발현자서재허다질병우기재면역상관질병중역분연착중요각색,재감염,자신면역,종류면역중소기적작용가위금후연구제공의거.
Autophagy is a degradation process within lysosomes/endosomes,which involves cell proliferation/differentiation and the homeostasis of intracellular enviroment.Genetic studies showed that autophagy is conservative in the evolutionary process,and autophagy related genes were found in many species from yeast to mammals,These studies indicated that autophagy may participate in physiological processes in these organisms.Recent researches showed that autophagy aslo plays key role in many diseases especially immune-related diseases.Here we reviewed the latest literatures on the role of autophagy in infection,autoimmunity and cancer.