CAJ | 학술논문

目的探讨吸入糖皮质激素/长效β2受体激动剂(信必可)治疗对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者肺功能进行性下降及气流阻力严重程度,以及患者急诊就诊率、住院率和住院天数的影响.方法选择82例符合入选标准的稳定期Ⅲ-Ⅳ级COPD患者,随机分为治疗组(42例)和对照组(40例),治疗组在常规治疗基础上,加用糖皮质激素/长效β2受体激动剂(160/4.5/μg,2次/d,长期吸入);对照组仅给予常规治疗.在两年的临床研究期间,观察记录两组患者急诊就诊率、住院率和住院天数,入组前及临床观察结束后对患者进行呼吸功能测定及支气管舒张试验.结果经2年的临床观察,治疗组患者FEV1进行性降低的程度显著低于对照组,深吸气量较对照组有明显改善(P值均＜0.05);治疗组两年期间的急诊就诊率、住院率及住院天数均低于对照组(P值均＜0.05).结论长期吸入糖皮质激素并长效β2受体激动剂能够延缓患者肺功能的进行性下降,并能降低患者的急性加重次数及住院时间,减轻患者的家庭及社会负担.
목적 탐토흡입당피질격소/장효β2수체격동제(신필가)치료대만성조새성폐질병(chronic obstructive pulmonary disease,COPD)환자폐공능진행성하강급기류조력엄중정도,이급환자급진취진솔、주원솔화주원천수적영향.방법 선택82례부합입선표준적은정기Ⅲ-Ⅳ급COPD환자,수궤분위치료조(42례)화대조조(40례),치료조재상규치료기출상,가용당피질격소/장효β2수체격동제(160/4.5/μg,2차/d,장기흡입);대조조부급여상규치료.재량년적림상연구기간,관찰기록량조환자급진취진솔、주원솔화주원천수,입조전급림상관찰결속후대환자진행호흡공능측정급지기관서장시험.결과 경2년적림상관찰,치료조환자FEV1진행성강저적정도현저저우대조조,심흡기량교대조조유명현개선(P치균＜0.05);치료조량년기간적급진취진솔、주원솔급주원천수균저우대조조(P치균＜0.05).결론 장기흡입당피질격소병장효β2수체격동제능구연완환자폐공능적진행성하강,병능강저환자적급성가중차수급주원시간,감경환자적가정급사회부담.
Objective To observe the efficacy of two-year therapy with glucocorticoid and long-acting beta 2-agonist(ICS+LABA)on lung function and acute exacerbation in patients with chronic obstructivepulmonary disease(COPD).Methods 82 patients were randomly allocated to standard therapy plus ICS+LABA 160/4.5 ttg twice a day or standard therapy alone over two-year period.Before and after two-year therapy,tung function was measured,and acute exacerbation and health status were compared between two groups.Results There were significant difference in forced expiratory volume per minute,inhaled capacity and acute exacerbation,health status between two groups(all P＜0.05).No obvious side effects were reported in both groups.Conclusion Inhaled ICS+LABA therapy may slow down lung function deereation and increase life quality.