中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2010年
11期
1474-1475
,共2页
麻醉,硬膜外,全身%T淋巴细胞%NK细胞
痳醉,硬膜外,全身%T淋巴細胞%NK細胞
마취,경막외,전신%T림파세포%NK세포
Anesthesia,epidural,general%T lymphocytes%Natural killer cell
目的 探讨不同麻醉方法对胆道手术患者免疫功能的影响.方法 64例ASA Ⅰ-Ⅱ级择期行胆道手术患者随机分为硬膜外麻醉组(硬麻组)和全身麻醉组(全麻组)各32例,观察两组T细胞亚群和自然杀伤(NK)细胞的变化.结果 两组麻醉后2h、术后1d、3d与麻醉前比较,CD3+、CD4+、CD4+/CD8+及NK细胞水平均明显下降(P<0.05),全麻组术后5d与麻醉前比较,CD3+、CD4+、CD4+/CD8+及NK细胞水平均明显下降(P<0.05);术后1d、3d、5d,全麻组与硬麻组比较,CD3+、CD4+细胞水平均明显下降(P<0.05),术后1d,全麻组与硬麻组比较,CD4+/CD8+及NK细胞水平均明显下降(P<0.05).结论麻醉对胆道手术患者免疫功能有一过性不同程度的抑制,其中全身麻醉较硬膜外麻醉更为明显.
目的 探討不同痳醉方法對膽道手術患者免疫功能的影響.方法 64例ASA Ⅰ-Ⅱ級擇期行膽道手術患者隨機分為硬膜外痳醉組(硬痳組)和全身痳醉組(全痳組)各32例,觀察兩組T細胞亞群和自然殺傷(NK)細胞的變化.結果 兩組痳醉後2h、術後1d、3d與痳醉前比較,CD3+、CD4+、CD4+/CD8+及NK細胞水平均明顯下降(P<0.05),全痳組術後5d與痳醉前比較,CD3+、CD4+、CD4+/CD8+及NK細胞水平均明顯下降(P<0.05);術後1d、3d、5d,全痳組與硬痳組比較,CD3+、CD4+細胞水平均明顯下降(P<0.05),術後1d,全痳組與硬痳組比較,CD4+/CD8+及NK細胞水平均明顯下降(P<0.05).結論痳醉對膽道手術患者免疫功能有一過性不同程度的抑製,其中全身痳醉較硬膜外痳醉更為明顯.
목적 탐토불동마취방법대담도수술환자면역공능적영향.방법 64례ASA Ⅰ-Ⅱ급택기행담도수술환자수궤분위경막외마취조(경마조)화전신마취조(전마조)각32례,관찰량조T세포아군화자연살상(NK)세포적변화.결과 량조마취후2h、술후1d、3d여마취전비교,CD3+、CD4+、CD4+/CD8+급NK세포수평균명현하강(P<0.05),전마조술후5d여마취전비교,CD3+、CD4+、CD4+/CD8+급NK세포수평균명현하강(P<0.05);술후1d、3d、5d,전마조여경마조비교,CD3+、CD4+세포수평균명현하강(P<0.05),술후1d,전마조여경마조비교,CD4+/CD8+급NK세포수평균명현하강(P<0.05).결론마취대담도수술환자면역공능유일과성불동정도적억제,기중전신마취교경막외마취경위명현.
Objective To observe the effects of different anesthesia methods on immune function of patients with biliary tract surgery in patients.Methods 64 patients with ASA Ⅰ～Ⅱ grade elective biliary tract surgery were randomly divided into general anesthesia group (n= 32) and epidural anesthesia group(n = 32) respectively.The changes of T cell subsets and natural killer(NK) cells were observed.Results The levels of CD3+ 、CD4+、 CD4+、CD8+ and NK cells after anesthesia 2h,postoperation 1d and 3d were significantly lower than those before anesthesia in two groups(P<0.05) .general anesthesia group after surgery 5d were significantly lower than those before anesthesia(P<0.05) ;After surgery 1d,3d and 5d,general anesthesia group was significantly lower than epidural anesthesia group (P<0.05) ;The levels of CD3+、CD4+ in general anesthesia group was significantly lower than epidural anesthesia group(P<0.05) ,after surgery 1 d,the levels of CD4+、 CD8+ and NK cells in epidural anesthesia group were significantly lower than those in general anesthesia group(P<0.05).Conclusion Anesthesia had an inhibition of transient varying degrees for the immune function of patients uaderwent biliary tract surgery,which general anesthesia was more evident than epidural anesthesia.
